Apparatus and methods for delivery of transcranial magnetic stimulation
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Abstract
Disclosed are apparatus and methods for delivery of transcranial magnetic stimulation. The apparatus includes a TMS coil which when energized generates an electric field substantially parallel to a long axis of the coil and substantially normal to a surface of the coil. Furthermore disclosed an apparatus for delivery of TMS in which a coil is adapted to a robotic member for computer-aided control and delivery. Further disclosed are methods of TMS planning and delivery in which subject images are utilized to plan, position and orient the TMS coil for precise delivery. Disclosed also are TMS coils having unique designs to better focus and direct magnetic stimulation.
201 Citations
63 Claims
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1-17. -17. (canceled)
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18. A method of transcranial magnetic stimulation, comprising:
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defining a cerebral cortical region of interest for a subject;
determining a stimulator position and orientation disposed to deliver an induced electric field substantially perpendicular to said cerebral cortical region of interest;
positioning said subject to immobilize said cerebral cortical region of interest;
directing said stimulator to said subject so that said stimulator is focused to said cerebral cortical region of interest, said directing based on said determined stimulator position and orientation; and
delivering said TMS to said subject, said delivering comprising generating an electric field substantially perpendicular to said cerebral cortical region of interest. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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27-50. -50. (canceled) claim 51. A method of transcranial magnetic stimulation, comprising:
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positioning a subject to receive the transcranial magnetic stimulation;
moving a transcranial magnetic stimulator to a first treatment position, the first treatment position computed to obtain maximum biological efficacy at a first target point of the subject; and
delivering the transcranial magnetic stimulation.
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52. The method of claim 51, further comprising delivering the transcranial magnetic stimulation via an electric field generated substantially perpendicular to the first target point.
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53. The method of claim 51, further comprising computing the first treatment position based on a functional image and an anatomical image of the subject.
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54. The method of claim 51, further comprising moving the transcranial magnetic stimulator to the first treatment position automatically.
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55. The method of claim 51, further comprising:
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moving the transcranial magnetic stimulator to a second treatment position; and
delivering the transcranial magnetic stimulation to the second treatment position.
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56. The method of claim 51, wherein delivering the transcranial magnetic stimulation comprises generating an electric field perpendicular to a sulcus, wherein the sulcus comprises the first target point.
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57. A method comprising:
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positioning a subject to receive transcranial magnetic stimulation;
locating a transcranial magnetic stimulator at a first treatment position that is perpendicular to a cerebral cortical region of interest of the subject; and
delivering the transcranial magnetic stimulation to the subject. - View Dependent Claims (58, 59, 60, 61, 62, 63)
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Specification