Cavity ring-down detection of surface plasmon resonance in an optical fiber resonator

• US 20050117157A1
• Filed: 12/23/2004
• Published: 06/02/2005
• Est. Priority Date: 12/12/2001
• Status: Active Grant

• Current Assignee: The Trustees of Princeton University (Princeton University)
• Original Assignee: The Trustees of Princeton University (Princeton University)
• Inventors: Tarsa, Peter B.
• Granted Patent: US 7,352,468 B2
• Time in Patent Office: Days
• US Class Current: 356/437
• CPC Class Codes: G01N 21/39 using tunable lasers
• CPC Class Codes: G01N 21/552 Attenuated total reflection
• CPC Class Codes: G01N 21/553 and using surface plasmons fluorescence excitation G01N21/648; enhanced Raman G01N21/658
• CPC Class Codes: G01N 21/554 detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
• CPC Class Codes: G01N 21/7746 the waveguide coupled to a cavity resonator

Abstract

An apparatus and method for use with a coherent optical source to detect environmental changes. The apparatus comprises: an optical cavity, including an input coupling port, and an optical fiber section; a detector optically coupled to the optical cavity to monitor radiation in the optical cavity; and a processor electrically coupled to the detector for analyzing the environmental changes adjacent the detection portion of the optical cavity based on a rate of decay of the radiation in the optical cavity monitored by the detector. The optical fiber section of the optical cavity includes a detection portion coated with a conductive layer capable of supporting a surface plasmon to provide cavity loss. The surface plasmon is responsive to the environmental changes adjacent the detection portion. The coherent optical source is optically coupled to the input coupling port of the optical cavity to provide the radiation in the optical cavity.

Claims

1. A fiber-based surface plasmon resonance (SPR) detector formed in an optical fiber section, the SPR detector comprising:

a tapered fiber portion of the optical fiber section having an outer surface; and

a conductive layer capable of supporting a surface plasmon formed on the outer surface of the tapered fiber portion, the surface plasmon being responsive to environmental changes adjacent the tapered fiber portion.

2. The SPR detector according to claim 1, wherein the tapered fiber portion is formed by heating and adiabatic stretching of the optical fiber section.

3. The SPR detector according to claim 1, wherein the conductive layer, comprises a metal film formed on the tapered fiber portion of the optical fiber section.

4. The SPR detector according to claim 1, wherein the conductive layer comprises a plurality of metal coated dielectric nano-particles, each dielectric nano-particle having a diameter less than about 1 μ

m.

5. The SPR detector according to claim 1, further comprising:

a functionalized chemical coating over the conductive layer, the functionalized chemical coating having a refractive index that is responsive to the environmental changes adjacent the tapered fiber portion.

6. The SPR detector according to claim 5, wherein the functionalized chemical coating is adapted to concentrate a predetermined analyte.

7. The SPR detector according to claim 5, wherein the functionalized chemical coating comprises a plurality of chemical coating sections, each chemical coating section adapted to concentrate a different predetermined analyte.

8. The SPR detector according to claim 5, wherein the environmental changes to which a refractive index of the functionalized chemical coating is responsive comprise at least one of:

a chemical composition of a fluid adjacent the tapered fiber portion;

an ambient temperature adjacent the tapered fiber portion;

humidity adjacent the tapered fiber portion;

a pH adjacent the tapered fiber portion;

an electric field adjacent the tapered fiber portion; and

ionizing radiation adjacent the tapered fiber portion.

9. The SPR detector according to claim 1, wherein the environmental changes to which the surface plasmon is responsive comprise a refractive index of material in contact with the conductive layer.

10. The SPR detector according to claim 1, wherein the optical fiber section is formed from one at least one of plastic, fused silica, sapphire, or fluoride based glass.

11. The SPR detector according to claim 1, wherein the optical fiber section is formed from a hollow optical fiber.

12. The SPR detector according to claim 1, wherein the optical fiber section is one of a single mode optical fiber or a multi-mode optical fiber.

13. The SPR detector according to claim 1, wherein the optical fiber section resonates at a wavelength between a visible region of an electromagnetic spectrum and a mid-infrared region of the electro-magnetic spectrum.

14. An apparatus for use with a coherent optical source to detect environmental changes, the apparatus comprising:

an optical cavity, comprising an input coupling port, and an optical fiber section, the optical fiber section comprises a detection portion coated with a conductive layer capable of supporting a surface plasmon to provide cavity loss, the surface plasmon responsive to the environmental changes adjacent the detection portion;

the coherent optical source optically coupled to the input coupling port of the optical cavity to provide radiation to the optical cavity;

a detector optically coupled to the optical cavity to monitor the radiation in the optical cavity; and

a processor electrically coupled to the detector for analyzing the environmental changes adjacent the detection portion of the optical cavity based on a rate of decay of the radiation in the optical cavity monitored by the detector.

15. The apparatus according to claim 14, wherein:

the optical cavity is a standing wave cavity tuned to a peak wavelength of the coherent optical source; and

a standing wave pattern formed in the standing wave cavity by radiation from the coherent optical source comprises a plurality of antinodes.

16. The apparatus according to claim 15, wherein:

the detector is optically coupled to at least one antinode of the standing wave pattern; and

the detection portion of the optical fiber section comprises at least one antinode of the standing wave pattern.

17. The apparatus according to claim 16, further comprising an output coupling port adjacent the at least one antinode optically coupled to the detector.

18. The apparatus according to claim 14, wherein the optical cavity is a traveling wave cavity.

19. The apparatus according to claim 18, wherein the optical cavity is a closed fiber optic ring formed by the optical fiber section.

20. The apparatus according to claim 14, wherein the input coupling port of the optical cavity is one of:

a grating coupler;

a high reflectivity mirror;

or

an evanescent fiber coupler.

21. The apparatus according to claim 14, wherein the optical fiber cavity further comprises at least one other optical fiber section, each optical fiber section comprising at least one detection portion.

22. The apparatus according to claim 14, wherein the detection portion of the optical fiber section is a tapered fiber portion.

23. The apparatus according to claim 22, wherein the tapered fiber portion is formed by heating and adiabatic stretching of the optical fiber section.

24. The apparatus according to claim 14, wherein the optical fiber section further comprises at least one other detection portion.

25. The apparatus according to claim 14, wherein the conductive layer coating the detection portion of the optical fiber section comprises a metal film formed on the detection portion of the optical fiber section.

26. The apparatus according to claim 14, wherein the conductive layer coating the detection portion of the optical fiber section comprises a plurality of metal coated dielectric nano-particles, each dielectric nano-particle having a diameter less than about 1 μ

m.

27. The apparatus according to claim 14, wherein:

the detection portion of the optical fiber section further comprises a functionalized chemical coating over the conductive layer coating; and

a refractive index of the functionalized chemical coating is responsive to the environmental changes adjacent the detection portion.

28. The apparatus according to claim 27, wherein the functionalized chemical coating is adapted to concentrate a predetermined analyte.

29. The apparatus according to claim 27, wherein the functionalized chemical coating comprises a plurality of chemical coating sections, each chemical coating section adapted to concentrate a different predetermined analyte.

30. The apparatus according to claim 27, wherein the environmental changes to which a refractive index of the functionalized chemical coating is responsive comprise at least one of:

a chemical composition of a fluid adjacent the detection portion;

an ambient temperature adjacent the detection portion;

humidity adjacent the detection portion;

a pH adjacent the detection portion;

an electric field adjacent the detection portion; and

ionizing radiation adjacent the detection portion.

31. The apparatus according to claim 14, wherein the environmental changes to which the surface plasmon is responsive comprise a refractive index of material in contact with the conductive layer.

32. The apparatus according to claim 14, wherein the optical fiber section is formed from at least one of plastic, fused silica, sapphire, or fluoride based glass.

33. The apparatus according to claim 14, wherein the optical fiber section is formed from a hollow optical fiber.

34. The apparatus according to claim 14, wherein the optical fiber section is one of a single mode optical fiber or a multi-mode optical fiber.

35. The apparatus according to claim 14, wherein the optical fiber section resonates at a wavelength between a visible region of an electro-magnetic spectrum and a mid-infrared region of the electro-magnetic spectrum.

36. The apparatus according to claim 14, wherein the optical fiber section is at least about 1 m long.

37. The apparatus according to claim 14, wherein the optical fiber section is at least about 10 m long.

38. The apparatus according to claim 14, wherein the optical fiber section is at least about 1 km long.

39. The apparatus according to claim 14, wherein the coherent optical source comprises at least one of an optical parametric generator or an optical parametric amplifier.

40. The apparatus according to claim 14, wherein the coherent optical source is a laser source.

41. The apparatus according to claim 40, wherein the laser source comprises one of a pulsed laser or a continuous wave laser.

42. The apparatus according to claim 40, wherein the laser source comprises one of an optical fiber laser or a tunable diode laser having a narrow band.

43. The apparatus according to claim 40, wherein the laser source is a single mode laser tunable in the wavelength region of about 400 nm and about 700 nm.

44. The apparatus according to claim 40, wherein the laser source is a single mode laser tunable in the wavelength region of about 1250 nm and about 1650 nm.

45. The apparatus according to claim 14, wherein the radiation provided to the optical cavity by the coherent optical source is single mode laser light having a predetermined peak wavelength.

46. The apparatus according to claim 45, wherein the predetermined peak wavelength is in a first range of about 400 nm to about 700 nm or a second range of about 1250 nm to about 1650 nm.

47. The apparatus according to claim 14, wherein:

the radiation provided to the optical cavity by the coherent optical source has a plurality of spectral peaks, each spectral peak having a corresponding peak wavelength;

the detector optically monitors each spectral peak of the radiation in the optical cavity separately; and

the processor analyzes the environmental changes adjacent the detection portion of the optical cavity based on a plurality of spectral peak rates of decay of corresponding to the plurality of spectral peak of the radiation in the optical cavity.

48. The apparatus according to claim 47, wherein the optical cavity comprises a plurality of detection portions, each detection portion having a corresponding conductive layer capable of supporting a corresponding surface plasmon to provide cavity loss at one corresponding peak wavelength.

49. The apparatus according to claim 48, wherein:

each detection portion of the optical fiber section further comprises a corresponding functionalized chemical coating;

each functionalized chemical coating is adapted to concentrate a corresponding predetermined analyte; and

a refractive index of each functionalized chemical coating is responsive to an amount of the corresponding predetermined analyte concentrated.

50. The apparatus according to claim 14, further comprising:

an optical isolator optically coupled between the coherent optical source and the input port of the optical cavity and in line with the radiation emitted from the coherent optical source such that the optical isolator minimizes noise from the coherent optical source.

51. The apparatus according to claim 14, wherein the detector is an inline electroabsorption monitor in the optical fiber section.

52. The apparatus according to claim 14, wherein:

the optical cavity further comprises an output port;

the output port comprises at least one of;

a grating coupler;

a high reflectivity mirror;

or

an evanescent fiber coupler; and

the detector is optically coupled to the optical cavity through the output port.

53. The apparatus according to claim 52, wherein the detector comprises at least one of a photodiode, a photoresistor, or a phototransistor.

54. The apparatus according to claim 52, wherein the apparatus further comprises a filter placed in an optical path between the output port and the detector to selectively pass a portion of the radiation from the optical cavity to the detector.

55. The apparatus according to claim 54, wherein the filter is a tunable filter.

56. The apparatus according to claim 14, further comprising an input detector for determining when the radiation from the coherent optical source is provided to the optical cavity.

57. The apparatus according to claim 56, further comprising optical source control means to deactivate the coherent optical source after the input detector determines that the coherent optical source has provided the radiation to the optical cavity.

58. The apparatus according to claim 57, wherein the control means and the input detector are electrically coupled to the processing means.

59. The apparatus according to claim 56, wherein:

the input detector is electrically coupled to the processor and transmits a trigger signal to the processor when the radiation from the coherent optical source is provided to the optical cavity; and

the processor begins analyzing the rate of decay of the radiation in the optical cavity when the trigger is received from the input detector.

60. An apparatus to detect binding events for use with a coherent source that emits radiation, the apparatus comprising:

a passive, closed fiber optic ring;

a sensor having a predetermined shape, a conductive coating, and being in line with the passive, closed fiber optic ring, the conductive coating capable of supporting a surface plasmon driven by a propagating field in the passive, closed fiber optic ring and responsive to a level of the binding events at a surface of the conductive coating;

coupling means for i) optically coupling at least a portion of the radiation emitted by the coherent source into the passive, closed fiber optic ring to generate the propagating field in the passive, closed fiber optic ring and ii) transmitting a detection portion of the propagating field from the passive, closed fiber optic ring;

a detector for detecting a power level of the detection portion of the propagating field transmitted by the coupling means and generating a signal responsive thereto; and

a processor electrically coupled to the detector for determining the level of the binding events on the surface of the conductive coating of the sensor based on a rate of decay of the power level of the detection portion of the propagating field detected by the detector.

61. The apparatus according to claim 60, wherein:

the predetermined shape of the sensor is a tapered portion formed between ends of the sensor; and

the predetermined shape is exposed to a surrounding fluid.

62. The apparatus according to claim 61, wherein the tapered portion is formed by heating and adiabatic stretching of a sensor section of the passive, closed fiber optic ring.

63. The apparatus according to claim 61, wherein the fluid is at least one of a gas, a liquid, or a suspension.

64. The apparatus according to claim 60, wherein the conductive coating of the sensor is excitable when a wavelength of the propagating field in the passive, closed fiber optic ring matches a characteristic plasmon resonance wavelength of the conductive coating.

65. The apparatus according to claim 64, wherein the sensor further comprises a functionalized chemical coating formed on the conductive coating.

66. The apparatus of claim 65, wherein the functionalized chemical coating is adapted to concentrate a predetermined analyte.

67. The apparatus according to claim 60, wherein the conductive coating of the sensor comprises a metal film.

68. The apparatus according to claim 60, wherein the conductive coating of the sensor comprises a plurality of metal coated dielectric nano-particles, each dielectric nano-particle having a diameter less than about 1 μ

m.

69. The apparatus according to claim 60, wherein the coupling means is a single optical coupler.

70. The apparatus according to claim 60, wherein the coupling means comprises i) a first optical coupler for optically coupling the portion of the radiation emitted by the coherent source into a first section of the passive, closed fiber optic ring and ii) a second optical coupler for transmitting the detection portion of the propagating field from a second section of the passive, closed fiber optic ring.

71. The apparatus according to claim 60, further comprising a filter placed in an optical path between the coupling means and the detector to selectively pass the detection portion of the propagating field transmitted by the coupling means from the passive, closed fiber optic ring to the detector.

72. The apparatus according to claim 71, wherein the filter selectively passes the detection portion of the propagating field to the detector based on a wavelength of the detection portion.

73. The apparatus according to claim 60, wherein the coherent source comprises at least one of:

an optical parametric generator;

an optical parametric amplifier;

or

a laser source.

74. The apparatus according to claim 60, further comprising:

an optical isolator coupled between the coherent source and the coupling means and in line with the radiation emitted by the coherent source such that the optical isolator minimizes noise reflected back into the coherent source.

75. The apparatus according to claim 60, wherein the surface plasmon generated on the surface of the conductive coating of the sensor dissipates the propagating field in the passive, closed fiber optic ring.

76. The apparatus according to claim 60, wherein the passive, closed fiber optic ring is formed from at least one of plastic, fused silica, sapphire, or fluoride based glass.

77. The apparatus according to claim 60, wherein the passive, closed fiber optic ring is formed from a hollow optical fiber.

78. The apparatus according to claim 60, wherein the passive, closed fiber optic ring is formed from one of a single mode optical fiber or a multi-mode optical fiber.

79. The apparatus according to claim 60, wherein a coupled power of the input portion of the radiation coupled into the passive, closed fiber optic ring is less than about 1% of an emitted power the radiation emitted by the coherent source.

80. The apparatus according to claim 60, wherein a coupled power of the input portion of the radiation coupled into the passive, closed fiber optic ring is variable.

81. The apparatus according to claim 80, wherein:

the coupled power of the input portion of the radiation is varied based on a loop loss within the passive, closed fiber optic ring; and

the loop loss is based on at least connector losses and fiber losses.

82. The apparatus according to claim 60, wherein a circumference of the passive, closed fiber optic ring is at least about 1 m.

83. The apparatus according to claim 60, wherein a circumference of the passive, closed fiber optic ring is at least about 10 m.

84. The apparatus according to claim 60, wherein a circumference of the passive, closed fiber optic ring is at least about 1 km.

85. An improved method of detecting environmental changes in a fluid using a surface plasmon cavity ring-down detection (SPCRD) system that comprises a surface plasmon resonance (SPR) sensor optically coupled within an optical cavity, the SPR sensor formed of a metal-coated tapered optical fiber section, the method comprising:

coupling coherent optical radiation into the optical cavity of the SPCRD system, the coherent optical radiation comprising a predetermined wavelength;

monitoring a power level of the coherent optical radiation in the optical cavity;

determining a baseline cavity loss of the optical cavity based on the monitored power level;

exposing the SPR sensor to the fluid;

determining a detection cavity loss of the optical cavity based on the monitored power level following exposure of the SPR sensor to the fluid; and

detecting environmental changes in the fluid based on differences between the baseline cavity loss and the detection cavity loss of the optical cavity.

86. The method according to claim 85, wherein:

the coherent optical radiation coupled into the optical cavity is constant wave optical radiation;

the baseline cavity loss is determined based on an average monitored power level of the coherent optical radiation in the optical cavity monitored before exposure of the SPR sensor to the fluid; and

the detection cavity loss is determined based on the average monitored power level of the coherent optical radiation in the optical cavity monitored after exposure of the SPR sensor to the fluid.

87. The method according to claim 85, wherein:

the coherent optical radiation coupling into the optical cavity is pulsed optical radiation;

the baseline cavity loss is determined) based on a rate of decay of the monitored power level of the coherent optical radiation in the optical cavity monitored before exposure of the SPR sensor to the fluid; and

the detection cavity loss is determined based on the rate of decay of the monitored power level of the coherent optical radiation in the optical cavity monitored after exposure of the SPR sensor to the fluid.