Compositions and methods for topical treatment of skin infection

• US 20050123620A1
• Filed: 12/04/2003
• Published: 06/09/2005
• Est. Priority Date: 12/04/2003
• Status: Active Grant

• Current Assignee: Chiou Consulting Incorporated
• Original Assignee: Chiou Consulting Incorporated
• Inventors: Chiou, Win L.
• Granted Patent: US 7,258,875 B2
• Time in Patent Office: Days
• US Class Current: 424/603
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals

Abstract

The present invention describes an extremely effective, simple, novel, inexpensive, safe and quick method to treat both acne and warts, each with a different etiology and different clinical symptoms, by topically applying an effective amount of one or more polyvalent metal compounds. The polyvalent metal compounds include, but are not limited to, bismuth compounds, zinc compounds, magnesium compounds, aluminum compounds, calcium compounds, copper compounds, titanium compounds, manganese compounds, chromium compounds, barium compounds and iron compounds. The present invention can also be applied to the treatment of rosacea. The present invention can also be employed to prevent scarring and to facilitate healing or elimination of the scars once formed.

Claims

1. A method for treating acne or warts comprising topically applying a therapeutically effective amount of one or more polyvalent metal compounds in a suitable dosage form to the area of lesion of the acne or warts.

2. The method of claim 1, where the polyvalent metal compound is selected from the group consisting of a bismuth compound, a zinc compound, a magnesium compound, an aluminum compound, a calcium compound, a copper compound, a titanium compound, a manganese compound, a chromium compound, a barium compound and an iron compound.

3. The method of claim 2, wherein a bismuth compound is selected from the group consisting of bismuth subsalicylate, bismuth chloride, bismuth oxide, bismuth subcarbonate, bismuth subgallate, bismuth subnitrate, bismuth phosphate, bismuth aluminate, bismuth salicylate, bismuth tribromophenate, bismuth dipropylacetate, bismuth citrate, bismuth subcitrate, bismuth ascorbate, bismuth subcarbonate, bismuth tartrate and colloidal bismuth subcitrate.

4. The method of claim 2, wherein a zinc compound is selected from the group consisting of zinc sulfate, zinc acetate, zinc gluconate, zinc chloride, zinc carbonate, zinc oxide, zinc oleate, zinc stearate, zinc propionate, zinc salicylate and zinc undecenoate.

5. The method of claim 2, wherein a magnesium compound is selected from the group consisting of magnesium acetate, magnesium ascorbate, magnesium carbonate, magnesium chloride, magnesium citrate, magnesium stearate, magnesium gluconate, magnesium hydroxide, magnesium salicylate, magnesium sulfate, magnesium salicylate, magnesium lactate and magnesium oxide.

6. The method of claim 2, wherein an aluminum compound is selected from the group consisting of aluminum acetate, aluminum carbonate, aluminum chloride, aluminum potassium sulfate, aluminum glycinate, aluminum hydroxide, aluminum lactate, aluminum oxide, aluminum subacetate, aluminum sulfate, aluminum salicylate, aluminum ammonium sulfate and aluminum phosphate.

7. The method of claim 2, wherein a calcium compound is selected from the group consisting of calcium acetate, calcium alginate, calcium benzoate, calcium carbonate, calcium chloride, calcium citrate, calcium gluconate, calcium hydroxide, calcium lactate, calcium phosphate, calcium stearate, calcium sulfate, calcium salicylate and calcium oxide.

8. The method of claim 2, wherein a copper compound is selected from the group consisting of copper gluconate, copper salicylate and copper sulfate.

9. The method of claim 2, wherein a titanium compound is selected from the group consisting of titanium dioxide, titanium peroxide, titanium salicylate and titanium tannate.

10. The method of claim 2, wherein an iron compound is selected from a group consisting of ferric chloride, ferric citrate, ferric oxide, ferric sulfate, ferrous ascorbate, ferrous carbonate, ferrous sulfate, ferrous gluconate, ferrous fumarate, ferrous glycine, ferrous salicylate and ferrous lactate.

11. The method of claim 2, wherein a manganese compound is selected from the group consisting of manganese acetate, manganese benzoate, manganese borate, manganese carbonate, manganese salicylate, manganese bromide, manganese iodide and manganese diiodide.

12. The method of claim 2, wherein a barium compound is selected from the group consisting of barium sulfate, barium hydroxide, barium chloride, barium carbonate, and barium sulphide.

13. The method of claim 2, wherein the polyvalent metal compound is selected from chromium potassium sulfate, chromium trichloride, chromium piconilate and chromium trioxide.

14. The method of claim 1, wherein the polyvalent metal compound is selected from aluminum potassium sulfate, aluminum acetate, aluminum lactate, aluminum ammonium sulfate, magnesium sulfate, magnesium lactate, magnesium gluconate, magnesium acetate, zinc sulfate, zinc acetate and zinc gluconate.

15. A method for treating rosacea comprising applying a therapeutically effective amount of one or more polyvalent metal compounds to the area of the infection.

16. The method of claim 15, wherein the polyvalent metal compound is selected from the group consisting of a bismuth compound, a zinc compound, a magnesium compound, an aluminum compound, a calcium compound, a copper compound, a titanium compound, a manganese compound, a chromium compound, a barium compound and an iron compound.

17. A method for preventing scar formation or for healing or sloughing of the scar once formed comprising topical application of a therapeutically effective amount of one or more polyvalent metal compounds to the area of the scar on the skin.

18. The method of claim 17, wherein the polyvalent metal compound is selected from the group consisting of a bismuth compound, a zinc compound, a magnesium compound, an aluminum compound, a calcium compound, a copper compound, a titanium compound, a manganese compound, a chromium compound, a barium compound and an iron compound.