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Acidic insulin preparations with improved stability

  • US 20050171009A1
  • Filed: 03/25/2005
  • Published: 08/04/2005
  • Est. Priority Date: 06/18/2002
  • Status: Active Grant
First Claim
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1. A pharmaceutical formulation comprising a polypeptide selected from the group consisting of bovine, porcine or human insulin, an insulin analogue, an insulin derivative, an active insulin metabolite and combinations thereof;

  • a surfactant or a combination of two or more surfactants;

    optionally a preservative or a combination of two or more preservatives;

    and optionally an isotonicizing agent, a buffer or buffers or a further excipient or excipients or a combination thereof;

    such pharmaceutical formulation being a clear solution having a pH in the range from 1 to 6.8.

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