Injection device

• US 20050177116A1
• Filed: 02/11/2005
• Published: 08/11/2005
• Est. Priority Date: 08/14/2002
• Status: Active Grant

• Current Assignee: TecPharma Licensing AG (Ypsomed Holding AG)
• Original Assignee: TecPharma Licensing AG (Ypsomed Holding AG)
• Inventors: Graf, Roney
• Granted Patent: US 7,678,085 B2
• Time in Patent Office: Days
• US Class Current: 604/208
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

An injection device for injecting selectable amounts of a substance includes an activating mechanism including an axially moveable operating button which can rotated in a resting position only, a tubular drive element non-rotatably connected to the operating button, an axially fixed and non-rotatable guiding element, and an axially moveable driven member held non-rotatably in the device. A rotational grid is operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position whereby a selected amount of the substance to be injected can be selectively varied. For example, a dosage inadvertently selected too large by rotating the operating button too far in one direction can, in accordance with the present invention, be reduced by rotating the operating button in the opposite direction. In some embodiments, the rotational grid is adapted to produce a clicking sound when the operating button is rotated.

Claims

1. An injection device for injecting selectable amounts of a substance, comprising:

an activating mechanism including an axially moveable operating button which can rotated in a resting position only;

a tubular drive element non-rotatably connected to the operating button;

an axially fixed and non-rotatable guiding element;

an axially moveable driven member held non-rotatably in the device; and

a rotational grid operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position whereby a selected amount of the substance to be injected can be selectively varied.

2. The injection device according to claim 1, wherein if too large an amount of the substance is inadvertently selected by rotating the operating button too far in one direction, the selected amount can be reduced by rotating the operating button in the opposite direction.

3. The injection device according to claim 1, wherein the rotational grid is adapted to produce a clicking sound when the operating button is rotated.

4. An injection device for administering an injectable product, in doses, from a product container provided with a piston, said injection device comprising:

activating means which can be driven manually and comprising;

an operating button on which axial movements and rotational movements can be performed;

a drive element non-rotatably connected to the operating button and which follows the movements of the operating button; and

a driven member which can be moved in an advancing direction of the piston, wherein, when the operating button is moved axially, the drive element can be shifted in the advancing direction of the piston from a resting position to an end position and back again and this movement can be transferred onto the driven member connected to the drive element; and

a rotational grid generally between non-rotatable and rotatable parts of the device and comprising at least two mutually opposing locking elements having a plurality of co-operating locking protrusions and locking recesses, wherein the locking elements are abutted against each other by a first restorer and, when the operating button is rotated in the resting position, the locking protrusions slide relative to the locking recesses producing a sound, and wherein the rotational grid is configured such that the operating button can be moved in two rotational directions in the resting position.

5. The injection device as set forth in claim 4, wherein the rotational grid comprises an upper and a lower disc and an intermediate disc arranged generally between them which respectively comprises, on its facing sides, at least one of locking protrusions and locking recesses respectively corresponding to the locking protrusions and locking recesses on the respective discs.

6. The injection device as set forth in claim 5, wherein the locking protrusions are formed as serrated protrusions running in the circumferential direction of the discs.

7. The injection device as set forth in claim 5, wherein the locking protrusions on mutually opposing sides of the intermediate disc are arranged at mutually flush angular positions.

8. The injection device as set forth in claim 5, wherein the locking protrusions on the upper and lower disc are arranged at angular positions offset with respect to each other.

9. The injection device as set forth in claim 4, wherein the operating button can only be axially adjusted to the end position when the rotational grid is locked.

10. The injection device as set forth in claim 9, wherein a number of locking bodies are arranged on the outer circumference of one of the operating button or an element arranged non-rotatably with respect to the operating button, wherein the number of locking bodies corresponds to the number of locking protrusions on the facing sides of the locking elements of the rotational grid.

11. The injection device as set forth in claim 4, wherein an ampoule holder comprises the lower disc or is coupled to it and is axially retracted towards the operating button against a restoring force of a second restoring element, such that the rotational grid locks.

12. The injection device as set forth in claim 11, wherein the second restorer is generally between a rear part of the injection device and the ampoule holder.

13. The injection device as set forth in claim 12, wherein a length of the ampoule and a length of a front part of the injection device are adjusted to each other, such that the rotational grid locks when the ampoule is inserted into the front part and the front and rear parts are connected to each other.

14. The injection device as set forth in claim 13, wherein the second restorer is a pressure spring which is not fully compressed when the front and rear parts are connected to each other.

15. The injection device as set forth in claim 14, wherein the restoring force of the second restorer is smaller than the restoring force of the first restorer.

16. The injection device as set forth in claim 5, wherein the activating means further comprises a guiding element for the driven member.

17. The injection device as set forth in claim 16, wherein the guiding element is fixedly connected to the rear part of the device and the driven member is mounted non-rotatably in the guiding element.

18. The injection device as set forth in claim 17, wherein the fixed guiding element is arranged in front of the drive element.

19. The injection device as set forth in claim 17, wherein the fixed guiding element is arranged behind the drive element.

20. The injection device as set forth in claim 5, wherein the driven member which can be moved in the advancing direction of the piston is non-rotatable with respect to a casing of the device, and wherein by rotating the operating button in the resting position, the driven member spaced apart from the piston can be moved in the advancing direction by the drive element in accordance with a piston path required for the respective amount of product to be injected, and wherein the driven member remains spaced apart from the piston, and while the drive element is transferred from the resting position to the end position, the driven member comes to rest on the piston, in order to shift the piston by the thus pre-selected piston path.

21. The device as set forth in claim 5, further comprising a 30-gauge or 31-gauge injection needle.

22. A method of injecting a selectable amount of a substance, comprising the steps of:

providing an injection device comprising an activating mechanism comprising an axially moveable operating button which can rotated in a resting position only, a tubular drive element non-rotatably connected to the operating button, an axially fixed and non-rotatable guiding element, an axially moveable driven member held non-rotatably in the device, and a rotational grid operationally between rotatable and non-rotatable components of the injection device such that the operating button can be moved two rotational directions when in the resting position, and

rotating the operating button to select an amount of the substance to be injected, wherein if too large an amount is inadvertently selected by rotating the operating button too far in one direction, the too large an amount can be reduced by rotating the operating button in the opposite direction.

23. The method according to claim 22, wherein the rotational grid is adapted to produce a sound when the operating button is rotated, the method further comprising assessing the amount selected by listening to the sound.