Monitoring fluid flow in the gastrointestinal tract

• US 20050182342A1
• Filed: 04/29/2004
• Published: 08/18/2005
• Est. Priority Date: 02/13/2004
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Traffas, Mark J., Dinsmoor, David A.
• Application Number:
  US10/835,425
• Publication Number:
  US 20050182342A1
• Time in Patent Office: Days
• US Class Current: 600/593
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/4211 Diagnosing or evaluating reflux
• CPC Class Codes: A61B 5/4233 oesophagus
• CPC Class Codes: A61B 5/4261 Evaluating exocrine secretion production A61B3/101 takes precedence
• CPC Class Codes: A61B 5/6882 Anchoring means
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4472 Wireless probes
• CPC Class Codes: A61B 8/56 Details of data transmission or power supply

Abstract

A sensor capable of sensing the flow of fluids is placed in the gastrointestinal tract. The sensor may be, for example, an ultrasonic flow sensor, an optical flow sensor, or a thermal convection flow sensor. A system for monitoring fluid flow in the gastrointestinal tract may include monitor configured for placement in the gastrointestinal tract that includes such a sensor. The monitor measures the flow of fluid in the gastrointestinal tract based on the output of the senor. The monitor may take the form of a capsule with a means or mechanism for attachment to a mucosal lining of the gastrointestinal tract. In exemplary embodiments, the sensor is placed in the esophagus, senses the flow of fluid from the stomach into the esophagus, and is used to diagnose gastroesophageal reflux disease (GERD).

Claims

1. A method for monitoring reflux flow of fluid from a stomach of a patient into an esophagus of the patient comprising:

receiving a signal from a flow sensor, wherein the sensor is included as part of a medical monitor located within the esophagus that includes a housing, and the sensor outputs the signal as a function of at least one of velocity and rate of fluid flow within the esophagus outside of the housing;

determining a direction of the fluid flow within the esophagus based on the signal; and

monitoring the reflux flow of fluid from the stomach into the esophagus based on the signal and the direction of the fluid flow.

2. The method of claim 1, wherein the sensor comprises an ultrasonic flow sensor.

3. The method of claim 1, wherein the sensor comprises an optical flow sensor.

4. The method of claim 1, wherein the sensor comprises at least one of an electromagnetic flow sensor, a temperature sensor, and a sensor that senses concentration of a component of the fluid.

5. The method of claim 1, wherein determining a direction of the fluid flow comprises identifying fluid flow in a first direction, and monitoring reflux flow of fluid comprises monitoring reflux flow of fluid based on the identification of fluid flow in the first direction.

6. The method of claim 5, further comprising determining at least one of a velocity and a rate of the fluid flow in the first direction, wherein monitoring reflux flow of fluid comprises monitoring reflux flow of fluid based on the at least one of the velocity and the rate of the fluid flow in the first direction.

7. The method of claim 5, wherein fluid flow in the first direction comprises fluid flow in a retrograde direction within the esophagus.

8. The method of claim 7, further comprising identifying fluid flow within the esophagus in a second direction that is toward the stomach, wherein monitoring reflux flow of fluid comprises monitoring reflux flow of fluid based on the identification of fluid flow in the second direction

9. The method of claim 8, further comprising determining at least one of a velocity and a rate of the fluid flow in the second direction, wherein monitoring reflux flow of fluid comprises monitoring reflux flow of fluid based on the at least one of the velocity and the rate of the fluid flow in the second direction.

10. The method of claim 1, wherein the monitor comprises a capsule.

11. The method of claim 1, further comprising:

guiding the monitor to an attachment site within the esophagus; and

attaching the monitor to a mucosal lining of the esophagus at the attachment site.

12. The method of claim 1, wherein the monitor is located proximate to a lower esophageal sphincter of the patient.

13. The method of claim 1, wherein monitoring reflux flow of fluid comprises measuring reflux flow of fluid based on the signal.

14. The method of claim 1, further comprising transmitting flow information to a receiver located outside a body of the patient.

15. A medical monitor comprising:

a housing;

a flow sensor to output a signal as a function of at least one of velocity and rate of fluid flow outside of the housing; and

a processor to determine a direction of the fluid flow based on the signal, and monitor reflux flow of fluid from a stomach to an esophagus based on the direction of the fluid flow and the signal.

16. The monitor of claim 15, wherein the sensor comprises an ultrasonic flow sensor.

17. The monitor of claim 15, wherein the sensor comprises an optical flow sensor.

18. The monitor of claim 15, wherein the sensor comprises at least one of an electromagnetic flow sensor, a temperature sensor, and a sensor that senses concentration of a component of the fluid.

19. The monitor of claim 15, further comprising a quadrature phase detector that receives the signal from the flow sensor and outputs another signal based on the signal received from the flow sensor, wherein the processor determines the direction of the fluid flow based on the signal output by the quadrature phase detector.

20. The monitor of claim 15, wherein the processor identifies fluid flow in a first direction based on the signal, and monitors reflux flow of fluid based on the identification of fluid flow in the first direction.

21. The monitor of claim 20, wherein the processor determines at least one of a velocity and a rate of the fluid flow in the first direction based on the signal, and monitors reflux flow of fluid based on the at least one of the velocity and the rate of the fluid flow in the first direction.

22. The monitor of claim 20, wherein fluid flow in the first direction comprises fluid flow in a retrograde direction within the esophagus.

23. The monitor of claim 22, wherein the processor identifies fluid flow within the esophagus in a second direction that is toward the stomach based on the signal, and monitors reflux flow of fluid based on the identification of fluid flow in the second direction.

24. The monitor of claim 23, wherein the processor determines at least one of a velocity and a rate of the fluid flow in the second direction based on the signal, and monitors reflux flow of fluid based on the at least one of the velocity and the rate of the fluid flow in the second direction.

25. The monitor of claim 15, wherein the processor measures the reflux flow of fluid based on the signal output by the sensor.

26. The monitor of claim 15, wherein the monitor comprises a capsule.

27. The monitor of claim 15, further comprising an attachment mechanism to attach the housing to a mucosal lining of the esophagus.

28. The monitor of claim 27, further comprising a chamber to receive tissue of the mucosal lining, wherein the attachment mechanism comprises a pin that advances through the tissue.

29. The monitor of claim 15, further comprising a transmitter, wherein the processor transmits flow information to a receiver located outside a body of a patient.

30. A medical monitor comprising:

a housing;

an attachment mechanism to attach the housing to a mucosal lining of a gastrointestinal tract; and

a flow sensor to sense fluid flow outside of the housing within the gastrointestinal tract.

31. The monitor of claim 30, wherein the sensor comprises an ultrasonic flow sensor.

32. The monitor of claim 30, wherein the sensor comprises an optical flow sensor.

33. The monitor of claim 30, wherein the sensor comprises at least one of an electromagnetic flow sensor, a temperature sensor, and a sensor that senses concentration of a component of the fluid.

34. The monitor of claim 30, further comprising a processor to monitor fluid flow based on a signal output by the sensor as a function of the fluid flow.

35. The monitor of claim 34, wherein the sensor outputs the signal as a function of at least one of velocity and rate of fluid flow.

36. The monitor of claim 34, wherein the processor measures fluid flow based on the signal.

37. The monitor of claim 34, further comprising a transmitter, wherein the processor transmits flow information to a receiver located outside of a patient via the transmitter.

38. The monitor of claim 34, wherein the housing is attached to a mucosal lining of an esophagus, and the processor monitors reflux flow of fluid from a stomach to the esophagus.

39. The monitor of claim 30, further comprising a chamber to receive tissue of the mucosal lining, wherein the attachment mechanism comprises a pin that advances through the tissue.

40. The monitor of claim 30, wherein the attachment mechanism is biodegradable.

41. A medical monitor comprising:

means for housing components of the medical monitor;

means for attaching the housing means to a mucosal lining of a gastrointestinal tract of a patient; and

means for monitoring fluid flow outside of the housing within the gastrointestinal tract.

42. The medical monitor of claim 41, wherein means for monitoring fluid flow comprises means for monitoring reflux flow of fluid from a stomach to an esophagus.

43. The medical monitor of claim 42, further comprising means for determining a direction of the fluid flow, wherein the means for monitoring comprises means for monitoring reflux flow of fluid from a stomach to an esophagus based on the direction.

44. The medical monitor of claim 41, wherein the means for attaching is biodegradable.

45. A system comprising:

a monitor that includes a housing, an attachment mechanism to attach the housing to a mucosal lining of a gastrointestinal tract, and a flow sensor to sense fluid flow within the gastrointestinal tract outside of the housing; and

a receiver to receive fluid flow measurement information from the monitor.

46. The system of claim 45, further comprising a delivery device to carry the monitor to a location within the gastrointestinal tract for attachment at the location.

47. The system of claim 46, wherein the delivery device includes a lumen for application of suction to the lining of the gastrointestinal tract.

48. A method for monitoring fluid flow within the gastrointestinal tract of a patient using a monitor that comprises a housing and a flow sensor, the method comprising:

guiding the monitor to an attachment site within the gastrointestinal tract;

attaching the monitor to a mucosal lining of the gastrointestinal tract at the attachment site; and

monitoring fluid flow within the gastrointestinal tract based on a signal output by the sensor.

49. The method of claim 48, wherein the attachment site is within the esophagus, and monitoring fluid flow comprises monitoring the reflux flow of fluid from the stomach into the esophagus based on the signal.

50. The method of claim 49, wherein monitoring the reflux flow comprises determining a direction of the fluid flow within the esophagus based on the signal, and identifying reflux flow of fluid comprises identifying reflux flow of fluid based on the direction of the fluid flow.

51. The method of claim 49, wherein the attachment site is located proximate to a lower esophageal sphincter of the patient.

52. The method of claim 49, further comprising diagnosing gastroesophageal reflux disease based on identification of reflux flow of fluid from the stomach into the esophagus.

53. The method of claim 48, wherein guiding the monitor to an attachment site comprises guiding the monitor to the attachment site via an endoscopic delivery device.