Multiple section parenteral drug delivery apparatus

• US 20050197654A1
• Filed: 12/09/2004
• Published: 09/08/2005
• Est. Priority Date: 12/12/2003
• Status: Abandoned Application

• Current Assignee: PhiloMetron Inc.
• Original Assignee: PhiloMetron Inc.
• Inventors: Drinan, Darrel D., Edman, Carl F., Lackey, Robert P.
• Application Number:
  US11/009,548
• Publication Number:
  US 20050197654A1
• Time in Patent Office: Days
• US Class Current: 604/891.1
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61J 15/00 Feeding-tubes for therapeutic purposes
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2039/0205 for injecting media
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body

Abstract

The invention relates to a parenteral therapeutic agent delivery device. The therapeutic agent delivery device has a disposable section and an implant section suitable for long term implantation within the tissue of a subject. When necessary, the disposable section can be detached from the implant section, and a new disposable section can be attached. The disposable section may contain a reservoir containing the therapeutic agent, a pump for dispensing the therapeutic agent, controlling circuitry for regulating the dispensing of the therapeutic agent, and transceiver circuitry and an antenna for wireless communication with external devices.

Claims

1. A parenteral therapeutic agent delivery device comprising:

an access port comprising a parenteral fluid delivery location, an interior lumenal space, and a first connection point;

a disposable section, configured for attachment to the body of a subject, comprising a reservoir configured to hold a therapeutic agent, a pumping device, controlling circuitry to regulate delivery of the therapeutic agent, and a second connection point configured to mate with said first connection point.

2. The device of claim 1, wherein the disposable section additionally comprises transceiver circuitry, an antenna, and a power source.

3. The device of claim 2, wherein the controlling circuitry is configured to utilize signals received via the antenna and the transceiver circuitry in regulating the delivery of the therapeutic agent.

4. The device of claim 1, wherein the disposable section additionally comprises an input device.

5. The device of claim 1, wherein the controlling circuitry is configured to utilize signals from the input device in regulating delivery of the therapeutic agent.

6. The device of claim 1, wherein the device additionally comprises sensors.

7. The device of claim 6, wherein the controlling circuitry is configured to process signals received from the sensors.

8. The device of claim 7, wherein the controlling circuitry is configured to utilize processed signals from the sensors in regulating the delivery of the therapeutic agent.

9. The device of claim 7, wherein the disposable section additionally comprises transceiver circuitry and an antenna, and wherein the controlling circuitry is configured to relay processed signals to an external device via the transceiver circuitry and antenna.

10. The device of claim 2, wherein the controlling circuitry is configured to transmit information regarding the delivery of the therapeutic agent via the transceiver circuitry and antenna.

25. The device of claim 4, additionally comprising a sensor, wherein the controlling circuitry is configured to process signals received from the sensor and utilize said processed signals in the regulation of the release of the fluid.

11. A parenteral fluid delivery device comprising:

an access port comprising a first connection point, a lumenal space in fluid communication with the first connection point, and a biofluid head, said biofluid head configured for long term implantation by incorporating features promoting cellular ingrowth and inhibiting fibrous encapsulation of at least a portion of the biofluid head; and

a disposable section, configured for attachment to the body of a subject, comprising a reservoir configured to hold fluid, a pumping device, controlling circuitry to regulate delivery of the fluid, and a second connection point.

12. The device of claim 11, said biofluid head comprising a plurality of passages extending from the lumenal space to an exterior surface of the biofluid head.

13. The device of claim 12, said biofluid head comprising an insert structure comprising said plurality of passages.

14. The device of claim 12, wherein the passages have a cross-sectional dimension which limits the ability of surrounding tissues and cells to enter the lumenal space.

15. The device of claim 12, wherein the plurality of passages have a cross-sectional dimension of less than about one micron at a point along their length.

16. The device of claim 12, wherein the plurality of passages have a cross-sectional dimension of less than about 250 nanometers at a point along their length.

17. The device of claim 12, wherein at least a portion of the exterior of the biofluid head has features intended to reduce fibrous encapsulation of at least said portion of the biofluid head.

18. The device of claim 11, said access port comprising a first electrode located at a point near said biofluid head, wherein said first electrode is configured to generate a current in conjunction with a counter electrode such that fibrous encapsulation of the region of the biofluid head close to the first electrode is minimized.

19. The device of claim 18, the access port additionally comprising a counter electrode, said first and counter electrodes being configured to generate an electric current such that movement of cells toward the region of the access port close to the counter electrode is increased.

20. The device of claim 19, said access port additionally comprising stabilization feature, and wherein said counter electrode is located near said stabilization feature.

21. The device of claim 20, wherein said stabilization feature comprises an ingrowth collar.

22. The device of claim 11, wherein said biofluid head is configured for implantation for 30 days or more.

23. The device of claim 11, wherein said biofluid head is configured for implantation for 90 days or more.

24. A parenteral fluid delivery device comprising:

an implant portion suitable for long-term implantation, comprising a parenteral fluid delivery location, a catheter-like construct defining a lumen, and a first connection point; and

a disposable portion, configured for attachment to the body of a subject, comprising a reservoir configured to hold fluid, a pumping device, controlling circuitry to regulate the release of the fluid, and a second connection point configured to detachably mate with said first connection point.

26. The device of claim 24, wherein the implant portion additionally comprises a stabilization feature.

27. The device of claim 26, wherein the stabilization feature comprises an ingrowth collar.

28. The device of claim 24, wherein said access port additionally comprises a first electrode, configured to generate an electric current in conjunction with a counter electrode such that movement of cells toward the region of the access port close to the counter electrode is increased.

29. The device of claim 24, wherein said implant portion is configured for implantation for 30 days or more.

30. The device of claim 24, wherein said implant portion is configured for implantation for 90 days or more.