Method of treating human skin and a skin care composition for use in such a method

• US 20050215538A1
• Filed: 06/11/2003
• Published: 09/29/2005
• Est. Priority Date: 06/11/2002
• Status: Active Grant

• Current Assignee: Estetra SPRL
• Original Assignee: Pantarhei Bioscience B.V.
• Inventors: Coelingh Bennink, Herman Jan Tijimen, Bunschoten, Evert Johannes, Holinka, Christian Franz
• Granted Patent: US 7,943,604 B2
• Time in Patent Office: Days
• US Class Current: 514/182
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 47/22 Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A cosmetic method of treating human skin by delivering an estrogenic component to said skin, the method comprising applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula
in which formula R₁, R₂, R₃, R₄ independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R₅, R₆, R₇ is a hydroxyl group; no more than 3 of R₁, R₂, R₃, R₄ are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Another aspect relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.

Claims

1-16. -16. (canceled)

17. A cosmetic method of treating human skin by delivering an estrogenic component to said skin, the method comprising applying to the skin a composition containing:

(i) at least 5 μ

g/g of an estrogenic component selected from the group consisting of;

substances represented by the following formula

in which formula R₁, R₂, R₃, R₄, independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms;

each of R₅, R₆, R₇ is a hydroxyl group;

no more than 3 of R₁, R₂, R₃, R₄ are hydrogen atoms;

precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and

mixtures of one or more of the aforementioned substances and/or precursors; and

(ii) a cosmetically acceptable vehicle.

18. The method according to claim 17, wherein R₃ represents a hydroxyl group or an alkoxy group.

19. The method according to claim 17, wherein at least 3 of the groups R₁, R₂, R₃, and R₄ represent hydrogen atoms.

20. The method according to claim 17, wherein the precursors are derivatives of the estrogenic substances wherein the hydrogen atom of at least one of the hydroxyl groups has been substituted by an acyl radical of a hydrocarbon carboxylic, sulfonic acid or sulfamic acid of 1-25 carbon atoms;

tetrahydrofuranyl;

tetrahydropyranal;

or a straight or branched chain glycosydic residue containing 1-20 glycosidic units per residue.

21. The cosmetic method according to claim 17, wherein the composition is applied in an effective amount to enhance proliferation of fibroblasts and/or epidermal skin cells.

22. The cosmetic method according to claim 17, wherein the composition is applied in an effective amount to improve skin thickness and/or skin elasticity.

23. The cosmetic method according to claim 17, wherein the composition is applied in an effective amount to improve or prevent the condition of wrinkled, lined, dry, flaky, aged or photodamaged skin.

24. The cosmetic method according to claim 17, wherein the composition contains at least 10 μ

g/g of the estrogenic component.

25. The cosmetic method according to claim 17, wherein the composition is applied to facial skin or skin of the neck.

26. The cosmetic method according to claim 17, wherein the composition is applied at least once a day during a period of at least 3 days.

27. The cosmetic method according to claim 17, wherein virtually all of the composition that has been applied to the skin, is allowed to penetrate said skin.

31. A skin care composition for topical administration containing:

(i) at least 5 μ

g/g of an estrogenic component as defined in claim 17;

and

(ii) a cosmetically acceptable vehicle.

32. The skin care composition according to claim 31, which composition is a lotion, salve or a cream.

28. A method of treating or preventing vaginal dryness, wherein the method comprises applying to the vaginal epithelium a composition containing:

(i) at least 5 μ

g/g of said estrogenic component; and

(ii) a cosmetically acceptable vehicle.

29. A method of promoting wound healing, wherein the method comprises applying to the wounded tissue or to tissue in the vicinity of the wound a composition containing:

(i) at least 5 μ

g/g of said estrogenic component; and

(ii) a cosmetically acceptable vehicle.

30. A method of treating or preventing acne, wherein the method comprises applying to the skin that is affected by acne or that is at risk of being affected by acne a composition containing:

(i) at least 5 μ

g/g of said estrogenic component; and

(ii) a cosmetically acceptable vehicle.