Method to retract a body vessel wall with remodelable material

• US 20050222661A1
• Filed: 03/31/2005
• Published: 10/06/2005
• Est. Priority Date: 04/01/2004
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Paul, Ram H. Jr.
• Granted Patent: US 8,216,299 B2
• Time in Patent Office: Days
• US Class Current: 623/1.100
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/3645 Connective tissue
• CPC Class Codes: A61L 27/367 Muscle tissue, e.g. sphincter

Abstract

The present invention provides remodelable materials for retracting the interior walls of a body vessel via remodeling processes. Also provided are methods, kits and devices for the same.

Claims

1. A method for retracting the lumen of a body vessel comprising:

implanting a remodelable material in contact with an interior wall of a body vessel, and maintaining the remodelable material in contact with the interior wall of the body vessel for a time sufficient to remodelably retract a portion of the body vessel radially inward within the lumen of the body vessel.

2. The method of claim 1, where the remodelable material comprises an extracellular matrix material.

3. The method of claim 1, where the remodelable material comprises at least two extracellular matrix materials.

4. The method of claim 1, where the remodelable material comprises two or more layers of extracellular matrix material.

5. The method of claim 1, where the remodelable material comprises an Elastin.

6. The method of claim 1, where the remodelable material comprises SIS.

7. The method of claim 1, where the body vessel is a vein.

8. The method of claim 6, where the vein comprises a venous valve, and the remodelable material is a first remodelable material that is implanted at a first distance upstream from the base of a venous valve;

the method further comprising the step of;

implanting a second remodelable material within the lumen of the body vessel at a second distance downstream from the base of the venous valve, such that the first remodelable material and the second remodelable material are maintained in contact with the wall of a body vessel.

9. The method of claim 6, where the vein comprises a venous valve and the remodelable material is implanted between about 1 mm-about 50 mm from the base of a leaflet of the venous valve, as measured along the interior wall of the body vessel.

10. The method of claim 1, where the remodelable material is deployed from an intraluminal delivery device.

11. A method for improving sphincter muscle function, comprising:

implanting a remodelable material within a lumen of a body vessel at a distance from a sphincter, such that the remodelable material is in contact with the wall of the body vessel;

where the distance between the remodelable material and sphincter is sufficient to remodelably retract the sphincter radially inward within the lumen of the body vessel;

where the body vessel is selected from the group consisting of;

an esophagus, a urethra, a small intestine and a large intestine.

12. The method of claim 11, where the method is a method for treating gastroesophageal reflux disease and the body vessel is an esophagus.

13. A method for treating venous valve insufficiency comprising:

implanting SIS in contact with the wall of a body vessel within a lumen of the body vessel at a distance from a base of a leaflet of a venous valve, the distance between the SIS and the base of the leaflet being sufficient to remodelably retract the base of the leaflet radially inward toward the interior of the body vessel.

14. A device for retracting the walls of a body vessel, comprising:

an intraluminal catheter delivery system operably connected to a remodelable material attached to a support, the catheter delivery system further comprising a means for measuring a distance within the lumen of a body vessel;

the remodelable material adapted to attach to the interior wall of a body vessel.

15. The device of claim 14, where the device further comprises a means for retaining the remodelable material prior to implantation.

16. The device of claim 14, where the device further comprises a protective sheath around the remodelable material prior to implantation.

17. The device of claim 14, where the device comprises an inflatable balloon that is expanded to deploy the remodelable material at a point of treatment.

18. The device of claim 14, where the support is a self-expanding support frame, where the remodelable material is attached to the support, and where the support expands to deploy the remodelable material at a point of treatment.

19. The device of claim 14, where the remodelable material has a surface defining one or more holes configured to secure the remodelable material against the inner wall of the body vessel.

20. The device of claim 14, where the remodelable material is treated prior to implantation by exposure of the remodelable substance to one or more substances selected from the group of:

heparin, PTX, and a cross-linking agent.