Human antibodies specific to kdr and uses thereof
First Claim
1. An isolated human antibody or fragment thereof which binds selectively to KDR.
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Accused Products
Abstract
The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.
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Citations
30 Claims
- 1. An isolated human antibody or fragment thereof which binds selectively to KDR.
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10. An isolated polynucleotide which comprises a nucleotide sequence that encodes an amino acid sequence selected from the group consisting of SEQ ID NO:
- 20, SEQ ID NO;
22, SEQ ID NO;
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26, SEQ ID NO;
29, SEQ ID NO;
31, SEQ ID NO;
33, SEQ ID NO;
35, SEQ ID NO;
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39, SEQ ID NO;
41, SEQ ID NO;
43, SEQ ID NO;
45, SEQ ID NO;
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51, and SEQ ID NO;
53. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
- 20, SEQ ID NO;
Specification