Process for treating a biological organism
First Claim
1. A process for treating of cells disposed within a biological organism, said process comprising directing a sonic energy wave at said cells, said sonic energy wave having a frequency and a power level, said frequency and said power level varying with time according to a predetermined treatment regimen.
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Accused Products
Abstract
A process for treating cells within a biological organism in which sonic energy is focused on cells within a biological organism while the frequency and/or the power level of such energy is varied. In addition there is provided a process for synergistically combining sonic energy and other forms of energy, or other therapeutic agents, in the treatment of cells in living organisms. Furthermore there is provided a process for assaying the efficacy of other therapeutic agents with sonic energy.
557 Citations
103 Claims
- 1. A process for treating of cells disposed within a biological organism, said process comprising directing a sonic energy wave at said cells, said sonic energy wave having a frequency and a power level, said frequency and said power level varying with time according to a predetermined treatment regimen.
- 19. A process for treating cells comprised of microtubules, wherein said cells are disposed within a biological organism, and wherein said microtubules have a resonant frequency, comprising the steps of contacting said cells with a first sonic energy, and thereafter contacting said cells with a second sonic energy, wherein said first sonic energy has a frequency that is below said resonant frequency of said microtubules, and said second sonic energy has a frequency that is above said resonant frequency.
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29. A process for treating cells comprised of microtubules, wherein said cells are disposed within a biological organism, and wherein said microtubules have a resonant frequency, comprising the step of contacting said cells with a first sonic energy without causing cavitation of said cells, wherein said first sonic energy has a frequency that is within the resonant frequency of such microtubules, and wherein said first sonic energy has a power level less than about 150 Watts/square centimeter.
- 30. A process for treating cells comprised of microtubules, wherein said cells are disposed within a biological organism, and wherein said microtubules have a resonant frequency, comprising the step of contacting said cells with a first sonic energy without causing said cells to increase in temperature by more than about 1.0 degree Celsius, wherein said first sonic energy has a frequency that is the resonant frequency of such microtubules.
- 34. A process for treating cells comprised of microtubules, wherein said cells are disposed within a biological organism, and wherein said microtubules have a resonant frequency, comprising the steps of contacting said cells with a first sonic energy and a second sonic energy, thereby causing said microtubules to break, wherein said first sonic energy has a frequency that is about 50% below the resonant frequency of said microtubules, and said second sonic energy has a frequency that is about 50% above said resonant frequency.
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39. A process for treating cells comprised of microtubules, wherein said cells are disposed within a biological organism, said process comprising:
- estimating a resonant frequency of said microtubules, and thereafter contacting said cells with a sonic energy having a swept frequency, said swept frequency being swept from an initial frequency to a final frequency, and wherein said resonant frequency is in the range between said initial and said final frequency.
- View Dependent Claims (40, 41)
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42. A process for treating cells disposed within a biological organism, said process comprising the steps of:
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(a) directing at said cells an incident sonic energy wave from a sonic energy emitter, said sonic energy emitter powered by a signal generator for supplying an input signal to said sonic energy emitter;
(b) detecting, with at least one sonic energy receiver, at least one sonic energy wave from said cells, and producing an electrical signal in response thereto; and
(c) storing, in a digital processing device, said input signal and said electrical signal, said electrical signal representing a response of said cells to said incident sonic energy wave. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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64. A process for treating cells disposed within a biological organism, said process comprising the steps of:
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(a) exposing said cells to a therapeutic agent while simultaneously directing at said cells an incident sonic energy wave from a sonic energy emitter, said sonic energy emitter powered by a signal generator for supplying an input signal to said sonic energy emitter;
(b) detecting, with at least one sonic energy receiver, at least one sonic energy wave from said cells, and producing an electrical signal in response thereto; and
(c) storing, in a digital processing device, said input signal and said electrical signal, said electrical signal representing a response of said cells to said therapeutic agent in combination with said incident sonic energy wave. - View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83)
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84. A process for assaying the efficacy of a therapeutic agent for treating cells disposed within a biological organism, said process comprising the steps of:
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(a) directing at said cells an incident sonic energy wave from a sonic energy emitter, said sonic energy emitter powered by a signal generator for supplying an input signal to said sonic energy emitter;
(b) detecting, with at least one sonic energy receiver, at least one sonic energy wave from said cells, and producing a first electrical signal in response thereto;
(c) storing, in a digital processing device, said input signal and said first electrical signal, said first electrical signal representing a response of said cells to said incident sonic energy wave;
(d) treating said cells with said therapeutic agent thereby producing treated cells;
(e) directing at said treated cells said incident sonic energy wave from said sonic energy emitter;
(f) detecting, with said at least one sonic energy receiver, at least one sonic energy wave from said treated cells, and producing a second electrical signal in response thereto; and
(g) storing, in said digital processing device, said second electrical signal, said second electrical signal representing a response of said treated cells to said incident sonic energy wave;
- View Dependent Claims (85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103)
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Specification