Venous pulse oximetry

• US 20050256386A1
• Filed: 01/31/2003
• Published: 11/17/2005
• Est. Priority Date: 01/31/2002
• Status: Active Grant

• Current Assignee: Sijung Hu
• Original Assignee: Loughborough University Enterprises Limited (Loughborough University)
• Inventors: Smith, Peter Richard, Chan, Fang Chiat Daniel, Hayes, Matthew James
• Granted Patent: US 7,263,395 B2
• Time in Patent Office: Days
• US Class Current: 600/335
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

A method of non-invasively measuring venous oxygen saturation, comprising: applying a pressure transducer at a first site on a body, applying a drive signal to the external pressure transducer at a predetermined frequency, to cause a series of pulsations of a predetermined magnitude in the venous blood volume in the vicinity of said first site, applying an oximeter device at a second site on the body, measuring output signals received from said oximeter device, said output signals containing a component representative of the modulation of venous blood volume due to said pulsations, deriving a measure of venous oxygen saturation from the frequency response of said output signals.

Claims

1. A method of non-invasively measuring venous oxygen saturation, comprising

applying a pressure transducer at a first site on a body,

applying a drive signal to the external pressure transducer at a predetermined frequency, to cause a series of pulsations of a predetermined magnitude in the venous blood volume in the vicinity of said first site,

applying an oximeter device at a second site on the body,

measuring output signals received from said oximeter device, said output signals containing a component representative of the modulation of venous blood volume due to said pulsations,

deriving a measure of venous oxygen saturation from the frequency response of said output signals.

2. A method according to claim 1 wherein the relationship between the distance between the first and second sites on the one hand, and the magnitude of the pulsations on the other hand, is such that a multiplicative term in the frequency spectrum of the measured signals, indicative of a disturbance to the arterial system, is minimised.

3. A method according to claim 1 wherein the frequency of the drive signal is chosen such that the pulsations are distinguishable from the heart rate.

4. A method according to claim 1 wherein the relationship between the frequency ω

_m of the pulsations caused by said drive signal and the heart rate ω

_HR is chosen to comply with the following conditions;

ω

_m≠

n(ω

_HR±

Δ

ω

_HR)
and
ω

_m±

(ω

_HR±

Δ

ω

_HR)≠

n(ω

_HR±

Δ

ω

_HR)

where n>

1

5. A method according to claim 3 wherein the frequency of the drive signal is determined iteratively on the basis of a real time measurement of the heart rate.

6. A method according to claim 1 wherein the magnitude the pulsations is controlled such that the arterial system is minimally disturbed.

7. A method according to claim 1 wherein the magnitude of the pulsations is controlled such as to cause a variation of less than 1% in the DC level of the received signal.

8. A method according to claim 7 wherein the magnitude of the pulsations is such as to cause a variation of approximately 0.1% in the DC level of the received signal.

9. A method according to claim 1 wherein the oximeter is placed on a digit and a further pressure transducer is placed away from a distal end of a limb, and arranged to occlude the supply of blood to and from said limb, and the measurement is performed during the period of occlusion.

10. A method according to claim 2 wherein the magnitude of the pulsations is determined by progressively increasing the pulsation magnitude and observing a frequency response of the output signals;

the appearance of a multiplicative term in the frequency spectrum being indicative of the maximum permissible magnitude having been reached.

11. A method according to claim 10, wherein, upon reaching the point where said multiplicative term appears, the pulsation magnitude is subsequently reduced to a point where the multiplicative term becomes insignificant.

12. A method according to claim 1, further including a calibration step, during which the spacing between the first and second sites is varied while the pulsation magnitude is held constant, in order to derive an optimum spacing.

13. A method according to claim 12, wherein the calibration step includes a further step of varying the pulsation magnitude while the spacing of the first and second sites is held constant.

14. A method according to claim 1, wherein a measure of arterial oxygen saturation is derived from the frequency response of said output signals, and the difference is levels of said arterial and venous oxygen saturation is representative of tissue oxygen consumption.

15. Apparatus for non-invasively measuring venous oxygen saturation comprising:

A pressure transducer for applying a series of pulsations to a first site on a body,

a pulse oximeter,

control means for controlling the frequency and/or magnitude of said pulsations, such that the venous blood volume is modulated,

signal processing means for extracting a value for venous oxygen saturation from signals received from said oximeter, said signals containing a component representative of a modulation of venous blood volume due to said pulsations.

16. A device according to claim 15 wherein said control means operates to control the relationship between the frequency ω

_m of the pulsations caused by said drive signal and the heart rate ω

_HR according to the following conditions;

ω

_m≠

n(ω

_HR±

Δ

ω

_HR)
and
ω

_m±

(ω

_HR±

Δ

ω

_HR)≠

n(ω

_HR±

Δ

ω

_HR)

where n>

1

17. A device according to claim 15 wherein the pressure transducer comprises an inflatable digit cuff supplied with air from an air pump.

18. A device according to claim 17 wherein said pressure transducer and said pulse oximeter are formed as an integral device.