Method for increasing muscle mass and strength through administration of adenosine triphosphate

• US 20050261238A1
• Filed: 02/28/2005
• Published: 11/24/2005
• Est. Priority Date: 06/04/2001
• Status: Active Grant

• Current Assignee: TSI Group Limited
• Original Assignee: TSI Group Limited
• Inventors: Zhou, Joe, Hynson, Richard B., Lee, Steve S.
• Granted Patent: US 7,629,329 B2
• Time in Patent Office: Days
• US Class Current: 514/47
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid

Abstract

The present invention is directed to compositions having an effective amount of Adenosine Triphosphate (“ATP”) sufficient to effect intracellular and extracellular concentrations of ATP in a mammal to improve anaerobic exercise capacity by increasing muscle size and/or strength and methods for using the same. Preferably, a gastric acid secretion inhibitory coating is applied to the effective amount of ATP in a manner that protects the ATP from degradation by gastric juices. ATP compositions of the present invention may be administered in nutraceutical or functional food dosage forms, including oral and non-oral delivery forms. In addition, the effective amount of ATP maybe combined with amino acids, botanicals, functional foods, herbals, nucleotides, nutraceuticals, nutrients, pharmaceuticals, proteins, and/or vitamins in an effort to enhance the targeted activity of the composition.

Claims

1-13. -13. (canceled)

14. A method for improving anaerobic exercise capacity in a mammal, the method comprising the step of administering an effective amount of Adenosine Triphosphate (“

ATP”

) to the mammal.

15. The method of claim 14, further comprising the step of increasing muscle strength of the mammal.

16. The method of claim 14, further comprising the step of increasing muscle mass of the mammal.

17. The method of claim 14, further comprising the step of increasing total lifting volume of the mammal.

18. The method of claim 14, wherein the effective amount of ATP administered to the mammal is between about 150 mg and about 850 mg.

19. The method of claim 14, wherein the effective amount of ATP administered to the mammal is between about 7 mg ATP/kg body weight and about 14 mg ATP/kg body weight of the-mammal.

20. The method of claim 14, wherein the step of administering is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, intranasal, and inhalation.

21. The method of claim 20, wherein the oral administration comprises a nutraceutical delivery form selected from tablet, capsule, powder, granule, microgranule, pellet, soft-gel, controlled-release form, liquid, solution, elixir, syrup, suspension, emulsion, and magma.

23. The method of claim 14, wherein a gastric acid secretion inhibitory coating is applied to the effective amount of ATP.

26. The method of claim 14, further comprising the step of introducing the effective amount of ATP into a functional food form selected from the group consisting of a bar, beverage, bread, cereal, cracker, egg, juice and juice drink, milk and soft cheese, mineral water, pasta, pasta sauce, probiotic drink, soya product, spread, energy beverage, yogurt, baby and/or children'"'"'s food, women'"'"'s supplement product, men'"'"'s supplement product, and meal replacement product.

27. The method of claim 14, further comprising the step of mixing the effective amount of ATP with one or more compounds selected from the group consisting of amino acids, botanicals, functional foods, herbals, nucleotides, nutraceuticals, nutrients, pharmaceuticals, proteins, and vitamins.

22. (canceled)

24. (canceled)

25. The method of claim 24, wherein the gastric acid secretion inhibitory coating comprises a range of between about 10% w/w to about 20 % w/w.

28. A method for improving anaerobic exercise capacity in a mammal, the method comprising the steps of:

administering an effective amount of Adenosine Triphosphate (“

ATP”

) to the mammal, wherein the effective amount of ATP administered to the mammal is between about 150 mg and about 850 mg; and

increasing muscle strength of the mammal.

29. The method of claim 28, further comprising the step of increasing muscle mass of the mammal.

30. The method of claim 28, further comprising the step of increasing total lifting volume of the mammal.

31. The method of claim 28, wherein the effective amount of ATP administered to the mammal is between about 7 mg ATP/kg body weight and about 14 mg ATP/kg body weight of the mammal.

32. The method of claim 28, wherein the step of administering is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, intranasal, and inhalation.

33. The method of claim 32, wherein the oral administration comprises a nutraceutical delivery form selected from tablet, capsule, powder, granule, microgranule, pellet, soft-gel, controlled-release form, liquid, solution, elixir, syrup, suspension, emulsion, and magma.

34. The method of claim 28, wherein a gastric acid secretion inhibitory coating is applied to the effective amount of ATP.

35. The method of claim 34, wherein the gastric acid secretion inhibitory coating comprises a range of between about 10% w/w to about 20 % w/w.

36. The method of claim 28, further comprising the step of introducing the effective amount of ATP into a functional food form selected from the group consisting of a bar, beverage, bread, cereal, cracker, egg, juice and juice drink, milk and soft cheese, mineral water, pasta, pasta sauce, probiotic drink, soya product, spread, energy beverage, yogurt, baby and/or children'"'"'s food, women'"'"'s supplement product, men'"'"'s supplement product, and meal replacement product.

37. The method of claim 28, further comprising the step of mixing the effective amount of ATP with one or more compounds selected from the group consisting of amino acids, botanicals, functional foods, herbals, nucleotides, nutraceuticals, nutrients, pharmaceuticals, proteins, and vitamins.

38. A method for improving anaerobic exercise capacity in a mammal, the method comprising the steps of:

administering an effective amount of Adenosine Triphosphate (“

ATP”

) to the mammal, wherein the effective amount of ATP administered to the mammal is between about 7 mg ATP/kg body weight and about 14 mg ATP/kg body weight of the mammal; and

increasing muscle mass of the mammal.

39. The method of claim 38, further comprising the step of increasing muscle strength of the mammal.

40. The method of claim 38, further comprising the step of increasing total lifting volume of the mammal.

41. The method of claim 38, wherein the effective amount of ATP administered to the mammal is between about 150 mg and about 850 mg.

42. The method of claim 38, wherein the step of administering is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, intranasal, and inhalation.

43. The method of claim 42, wherein the oral administration comprises a nutraceutical delivery form selected from tablet, capsule, powder, granule, microgranule, pellet, soft-gel, controlled-release form, liquid, solution, elixir, syrup, suspension, emulsion, and magma.

44. The method of claim 38, wherein a gastric acid secretion inhibitory coating is applied to the effective amount of ATP.

45. The method of claim 44, wherein the gastric acid secretion inhibitory coating comprises a range of between about 10% w/w to about 20 % w/w.

46. The method of claim 38, further comprising the step of introducing the effective amount of ATP into a functional food form selected from the group consisting of a bar, beverage, bread, cereal, cracker, egg, juice and juice drink, milk and soft cheese, mineral water, pasta, pasta sauce, probiotic drink, soya product, spread, energy beverage, yogurt, baby and/or children'"'"'s food, women'"'"'s supplement product, men'"'"'s supplement product, and meal replacement product.

47. The method of claim 38, further comprising the step of mixing the effective amount of ATP with one or more compounds selected from the group consisting of amino acids, botanicals, functional foods, herbals, nucleotides, nutraceuticals, nutrients, pharmaceuticals, proteins, and vitamins.