Use of representations of DNA for genetic analysis
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Abstract
It is an object of the present invention to provide a solution to problems associated with the use of microarray technology for the analysis DNA. The present invention provides compositions and methods for the use of simple and compound representations of DNA in microarray technology. The present invention is also directed to methods for the production of High Complexity Representations (HCRs) of the DNA from cells.
64 Citations
42 Claims
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1-38. -38. (canceled)
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39. A method of hybridizing nucleic acids from a sample to a DNA microarray, the method comprising
providing a microarray that consists essentially of a plurality of nucleic acid probes from a representation of a reference genomic DNA, and contains or is suspected of containing sequences complementary to said nucleic acids, and contacting said microarray with said nucleic acids under conditions that allow hybridization between said nucleic acids and said nucleic acid probes to occur.
Specification