Devices and methods for measuring and enhancing drug or analyte transport to/from medical implant
First Claim
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1. A method of enhancing the transport of drug from an implanted drug delivery device across a tissue capsule, the method comprising:
- controllably releasing a drug formulation from a plurality of discrete reservoirs located in medical device implanted in a patient; and
controllably releasing an effective amount of a transport enhancer from said medical device implanted in a patient, to facilitate transport of the released drug formulation through a fibrous tissue capsule, if any, which exists around the device at the site of implantation.
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Abstract
Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
267 Citations
34 Claims
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1. A method of enhancing the transport of drug from an implanted drug delivery device across a tissue capsule, the method comprising:
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controllably releasing a drug formulation from a plurality of discrete reservoirs located in medical device implanted in a patient; and
controllably releasing an effective amount of a transport enhancer from said medical device implanted in a patient, to facilitate transport of the released drug formulation through a fibrous tissue capsule, if any, which exists around the device at the site of implantation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of enhancing the transport of drug from an implanted drug delivery device and across a tissue capsule, the method comprising:
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controllably releasing a drug formulation, which comprises charged drug molecules, from a plurality of discrete reservoirs of a medical device implanted into a patient, the release of the drug and the release of the enhancing agent being from one or more reservoirs located in the device; and
utilizing an electromotive method to enhance transport of the charged drug molecules through a tissue capsule, if any, surrounding the implanted medical device. - View Dependent Claims (21, 22)
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23. A method of enhancing the transport of an analyte to a sensor device implanted in a patient, the method comprising:
controllably releasing an effective amount of a transport enhancer from the implanted sensor device, said device comprising a plurality of discrete reservoirs having sensors located therein. - View Dependent Claims (24)
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25. An implantable medical device comprising:
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a body portion;
two or more reservoirs located in and defined by the body portion;
reservoir contents in the reservoirs; and
means for enhancing mass transport, of all or a portion of the reservoir contents or of an environmental component intended for contact with all or a portion of the reservoir contents, through any fibrous tissue capsule that may form around the device following implantation. - View Dependent Claims (26, 27, 28, 29, 30, 31)
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32. An implantable device for testing drug or analyte transport through a tissue capsule, the device comprising:
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a primary body having an outer surface, a perfusate fluid inlet, a perfusate fluid outlet, and a fluid conduit extending between the inlet and the outlet;
a substrate attached to the primary body;
at least one reservoir defined in and extending through the substrate, the reservoir having a first opening in the fluid conduit and a second opening which can be open to the outer surface of the device;
at least one reservoir cap covering the second opening of the reservoir;
means for selectively disintegrating or removing the reservoir cap. - View Dependent Claims (33)
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34. The device of claim 34, further comprising a semipermeable barrier structure blocking bulk fluid flow through one or both of the reservoir openings following reservoir cap disintegration or removal.
Specification