Therapeutic polyanhydride compounds for drug delivery

• US 20060013851A1
• Filed: 02/06/2003
• Published: 01/19/2006
• Est. Priority Date: 02/07/2002
• Status: Abandoned Application

• Current Assignee: Rutgers University
• Original Assignee: Rutgers University
• Inventors: Giroux, Karen J
• Application Number:
  US10/504,121
• Publication Number:
  US 20060013851A1
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61K 47/59 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
• CPC Class Codes: A61K 47/595 Polyamides, e.g. nylon polyamino acids A61K47/62
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/604 Biodegradation
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C08L 73/02 Polyanhydrides

Abstract

Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol, or phenol group within their structure into polymeric drug delivery systems are provided. Also provided are methods of producing polymeric drug delivery systems via these polyanhydride linkers as well as methods of administering low molecular weight drug to a host via the polymeric drug delivery systems. Medical implants based on the polymeric drug delivery system of the invention are also provided.

Claims

1. (canceled)

2. (canceled)

3. A method of treating arthritis comprising injecting into the area of the arthritis an effective amount of a polyanhydride comprising a polymer whose backbone incorporates linkages selected from the group consisting of ester, thioester, and amide wherein the backbone also incorporates at least one group which will yield a biologically-active anti-inflammatory upon the hydrolysis of the polymer, and further wherein the polymer comprises one or more units of Formula I:

—

C(═

O)R¹—

X—

R²—

X—

R¹—

C(═

O)—

O—

 

 

(I)

wherein each R¹ is a group that will provide a therapeutically active anti-inflammatory compound upon hydrolysis of the polymer;

each X is independently an amide linkage, a thioester linkage, or an ester linkage; and

R² is a linking group;

provided that the therapeutically active compound is not an ortho-hydroxy aryl carboxylic acid.