Method and apparatus for controlled gene or protein delivery
First Claim
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1. A system, comprising:
- an implantable pulse generator including;
a sensor to sense a physiological signal indicative of a predetermined cardiac condition;
an event detector, coupled to the sensor, to detect the predetermined cardiac condition from the physiological signal; and
an implant controller coupled to the event detector, the implant controller including a gene or protein delivery control module adapted to produce an electrical signal to control gene or protein delivery in response to the predetermined cardiac condition; and
an implantable gene or protein delivery device coupled to the implantable pulse generator, the implantable gene or protein delivery device including a polymer matrix and isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA, or isolated protein, which nucleic acid or protein is released from the implantable gene or protein delivery device in response to an electric field created by the electrical signal.
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Abstract
An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delivers gene(s) and/or protein(s) in conjunction with delivering pacing and/or defibrillation pulses.
188 Citations
109 Claims
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1. A system, comprising:
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an implantable pulse generator including;
a sensor to sense a physiological signal indicative of a predetermined cardiac condition;
an event detector, coupled to the sensor, to detect the predetermined cardiac condition from the physiological signal; and
an implant controller coupled to the event detector, the implant controller including a gene or protein delivery control module adapted to produce an electrical signal to control gene or protein delivery in response to the predetermined cardiac condition; and
an implantable gene or protein delivery device coupled to the implantable pulse generator, the implantable gene or protein delivery device including a polymer matrix and isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA, or isolated protein, which nucleic acid or protein is released from the implantable gene or protein delivery device in response to an electric field created by the electrical signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 52, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109)
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43. A method for operating an implantable gene or protein delivery system, comprising:
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sensing a physiological signal indicative of a predetermined cardiac condition using an implantable sensor;
detecting the predetermined cardiac condition from the physiological signal; and
producing an electrical signal in response to the predetermined cardiac condition, which electric signal is effective to create an electric field which is capable of releasing nucleic acid or protein from an implantable gene or protein delivery device including a polymer matrix and isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA or isolated protein. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 94)
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79. A method to prepare an implantable gene or protein delivery device including isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising:
introducing to a physiologically compatible polymer matrix the isolated nucleic acid or isolated protein so as to yield an implantable gene or protein delivery device, wherein the isolated nucleic acid or protein is selected so as to prevent, inhibit or treat a cardiac condition in a mammal, and wherein the rate of release of the nucleic acid or protein from the device is capable of being controlled by an electric signal. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 95)
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80. A method to prepare an implantable gene or protein delivery device including isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising:
combining physiologically compatible monomers suitable to form a polymeric matrix and the isolated nucleic acid or isolated protein so as to yield an implantable gene or protein delivery device, wherein the isolated nucleic acid or protein is selected so as to prevent, inhibit or treat a cardiac condition in a mammal, and wherein the rate of release of the nucleic acid or protein from the device is capable of being controlled by an electric signal.
Specification