Process for treating a biological organism
First Claim
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1. A process for treating a biological organism, comprising the steps of:
- (a) administering a cell cycle arresting drug to said organism, thereby producing synchronized cells within such organism, (b) administering a microtubule stabilizing drug to said organism, thereby producing synchronized cells whose microtubules have been stabilized within said organism, and (c) contacting said synchronized cells whose microtubules have been stabilized with mechanical vibrational energy.
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Abstract
A biological organism suffering from cancer can be treated by administering a cancer cell cycle arresting drug; optionally administering a microtubule stabilizing agent; and exposing the cell cycle arrested cells to mechanical vibrational energy. The method selectively induces apoptosis in cancer cells.
210 Citations
58 Claims
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1. A process for treating a biological organism, comprising the steps of:
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(a) administering a cell cycle arresting drug to said organism, thereby producing synchronized cells within such organism, (b) administering a microtubule stabilizing drug to said organism, thereby producing synchronized cells whose microtubules have been stabilized within said organism, and (c) contacting said synchronized cells whose microtubules have been stabilized with mechanical vibrational energy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A process for initiating apoptosis in a cancer cell comprising:
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(a) contacting the cell with a cell cycle arresting drug; and
(b) contacting said cell with mechanical vibrational energy. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37)
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38. A method for treating a patient suffering from cancer comprising administering to said patient an amount of a cell cycle arresting drug sufficient to synchronize cell cycles of a plurality of cancer cells in said patient;
- and subjecting said cells to mechanical vibrational energy.
- View Dependent Claims (39, 40, 41)
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42. A method of treating a patient suffering from cancer comprising administering to said patient an amount of a cell cycle arresting drug sufficient to synchronize cell cycles of a plurality of cancer cells in the patient;
- administering to the patient a microtubule stabilizing agent; and
exposing the patient to mechanical vibrational energy. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51)
- administering to the patient a microtubule stabilizing agent; and
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52. A process for treating a patient suffering from cancer comprising administering to said patient an amount of a cell cycle arresting drug sufficient to synchronize cell cycles of a plurality of the cancer cells in said patient;
- administering to said patient radiation therapy sufficient to stabilize microtubule assembly in said cancer cells; and
subjecting said cancer cells to mechanical vibrational energy.
- administering to said patient radiation therapy sufficient to stabilize microtubule assembly in said cancer cells; and
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53. A method of treating a patient suffering from cancer comprising administering to said patient a cancer cell cycle arresting amount of gemcytabine;
- administering a microtubule stabilizing agent selected from the group consisting of taxanes, coumarins, magnetic derivatives thereof, and combinations thereof; and
exposing the patient to mechanical vibrational energy of frequency of about 50 megahertz to about 2 gigahertz. - View Dependent Claims (54)
- administering a microtubule stabilizing agent selected from the group consisting of taxanes, coumarins, magnetic derivatives thereof, and combinations thereof; and
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55. A method of treating a patient suffering from cancer comprising administering to said patient an amount of a cell cycle arresting drug sufficient to synchronize cell cycles of a plurality of cancer cells in the patient;
- administering to the patient a magnetic microtubule stabilizing agent;
applying a localized magnetic field to increase the concentration of magnetic microtubule stabilizing agent at a predetermined location in the patient; and
exposing the patient to mechanical vibrational energy. - View Dependent Claims (56, 57, 58)
- administering to the patient a magnetic microtubule stabilizing agent;
Specification