Devices and methods for interstitial injection of biologic agents into tissue
First Claim
1. A method for injecting platelet gel into ischemic tissue of a heart of a patient, the method comprising:
- providing a source of platelet plasma;
providing a source of thrombin;
providing an injection device fluidly coupled to the source of platelet plasma and the source of thrombin and including a first needle for separately injecting platelet plasma into tissue and a second needle for separately injecting thrombin into tissue;
making an opening into the patient;
advancing the first and second needles of the injection device through the opening to the heart;
identifying ischemic tissue of the heart;
driving the first and second needles of the injection device into the ischemic tissue; and
injecting the platelet plasma and the thrombin separately into the ischemic tissue, wherein the platelet plasma and the thrombin combine within the ischemic tissue to form a platelet gel.
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Abstract
The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
215 Citations
25 Claims
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1. A method for injecting platelet gel into ischemic tissue of a heart of a patient, the method comprising:
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providing a source of platelet plasma;
providing a source of thrombin;
providing an injection device fluidly coupled to the source of platelet plasma and the source of thrombin and including a first needle for separately injecting platelet plasma into tissue and a second needle for separately injecting thrombin into tissue;
making an opening into the patient;
advancing the first and second needles of the injection device through the opening to the heart;
identifying ischemic tissue of the heart;
driving the first and second needles of the injection device into the ischemic tissue; and
injecting the platelet plasma and the thrombin separately into the ischemic tissue, wherein the platelet plasma and the thrombin combine within the ischemic tissue to form a platelet gel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification