Micropressors, devices and methods for use in analyte monitoring systems
First Claim
1. One or more microprocessors, comprising programming to control:
- selecting a current integration method for an analyte-related current signal, wherein (i) said analyte-related current signal comprises data points, (ii) an electrode system comprising two or more electrode sets is used for detecting said analyte-related current signal, each electrode set comprises an iontophoretic electrode and an electrochemical sensor element, wherein each of the two iontophoretic electrodes alternately function as cathode and anode, (iii) a current signal, comprising data points, is detected in a half-measurement cycle at each of the anode and the cathode, and (iv) the analyte-related current signal is obtained from the sensor element associated with the cathode;
determining a background baseline for a given sensor when associated with the cathode based on the last two data points of the current signal detected for the same sensor in a previous half-cycle when the sensor was associated with the anode; and
subtracting the background baseline from the analyte-related current signal and if over-subtraction of the analyte-related current signal occurs, employing one of the following integration methods to determine an analyte-related charge signal based on the analyte-related current signal;
(i) stopping integration when the maximum integral is reached and using the maximum integral as the analyte-related charge signal;
or (ii) recalculating a background baseline based on the last two data points from the analyte-related current signal at the cathode;
subtracting the recalculated background baseline from the analyte-related current signal, and integrating the background subtracted analyte-related current signal to obtain the analyte-related charge signal.
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Abstract
The present invention comprises one or more microprocessors programmed to execute methods for improving the performance of an analyte monitoring device including prediction of glucose levels in a subject by utilizing a predicted slower-time constant (1/k2). In another aspect of the invention, pre-exponential terms (1/c2) can be used to provide a correction for signal decay (e.g., a Gain Factor). In other aspects, the present invention relates to one or more microprocessors comprising programming to control execution of (i) methods for conditional screening of data points to reduce skipped measurements, (ii) methods for qualifying interpolated/extrapolated analyte measurement values, (iii) various integration methods to obtain maximum integrals of analyte-related signals, as well as analyte monitoring devices comprising such microprocessors. Further, the present invention relates to algorithms for improved optimization of parameters for use in prediction models that require optimization of adjustable parameters.
245 Citations
3 Claims
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1. One or more microprocessors, comprising programming to control:
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selecting a current integration method for an analyte-related current signal, wherein (i) said analyte-related current signal comprises data points, (ii) an electrode system comprising two or more electrode sets is used for detecting said analyte-related current signal, each electrode set comprises an iontophoretic electrode and an electrochemical sensor element, wherein each of the two iontophoretic electrodes alternately function as cathode and anode, (iii) a current signal, comprising data points, is detected in a half-measurement cycle at each of the anode and the cathode, and (iv) the analyte-related current signal is obtained from the sensor element associated with the cathode;
determining a background baseline for a given sensor when associated with the cathode based on the last two data points of the current signal detected for the same sensor in a previous half-cycle when the sensor was associated with the anode; and
subtracting the background baseline from the analyte-related current signal and if over-subtraction of the analyte-related current signal occurs, employing one of the following integration methods to determine an analyte-related charge signal based on the analyte-related current signal;
(i) stopping integration when the maximum integral is reached and using the maximum integral as the analyte-related charge signal;
or (ii) recalculating a background baseline based on the last two data points from the analyte-related current signal at the cathode;
subtracting the recalculated background baseline from the analyte-related current signal, and integrating the background subtracted analyte-related current signal to obtain the analyte-related charge signal. - View Dependent Claims (2, 3)
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Specification