Method for treating gastrointestinal disorder

  • US 20060063830A1
  • Filed: 09/01/2005
  • Published: 03/23/2006
  • Est. Priority Date: 09/02/2004
  • Status: Active Grant
First Claim
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1. A method for the long term treatment of gastrointestinal disorders in a human subject, which comprises administering to the subject in need thereof an effective amount of a prostaglandin compound represented by Formula (I) and/or its tautomer:

  • embedded image wherein W1 and W2 are embedded image R3 and R4 are hydrogen;

    or one of them is OH and the other is hydrogen;

    X1 and X2 are hydrogen, lower alkyl or halogen, provided that at least one of them is halogen;

    R2 is hydrogen or alkyl;

    Y is a saturated or unsaturated C2-10 hydrocarbon chain, which is unsubstituted or substituted by oxo, halogen, alkyl, hydroxy or aryl;

    A is —

    CH2OH, —

    COCH2OH, —

    COOH or its functional derivative;

    R1 is a saturated or unsaturated, straight chain-, branched chain- or ring-forming lower hydrocarbon, which is unsubstituted or substituted by halogen, oxo, hydroxy, lower alkyl, lower alkoxy, lower alkanoyloxy, lower cycloalkyl, lower cycloalkyloxy, aryl, or aryloxy;

    lower cycloalkyl;

    lower cycloalkyloxy;


    or aryloxy;

    the bond between C-13 and C-14 positions is double or single bond, and the steric configuration at C-15 position is R, S or a mixture thereof.

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