Solid dosage form comprising a fibrate
First Claim
Patent Images
1. A solid oral dosage form comprising a fibrate dissolved in a vehicle, which is hydrophobic, hydrophilic or water-miscible.
6 Assignments
0 Petitions
Accused Products
Abstract
The invention provides stable, solid dosage forms and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved in an non-aqueous vehicle in order to ensure improved bioavailability of the active ingredient upon oral administration relative to known fibrate formulations.
51 Citations
61 Claims
- 1. A solid oral dosage form comprising a fibrate dissolved in a vehicle, which is hydrophobic, hydrophilic or water-miscible.
- 47. A composition comprising a fibrate dissolved in a vehicle, which is hydrophobic, hydrophilic or water-miscible.
-
59. A solid composition in particulate form comprising a fibrate, a hydrophobic or a hydrophilic or water-miscible vehicle and an oil-sorption material, which composition exhibits an oil threshold value of at least 10%, and which composition further fulfills one or both of i) and ii):
-
i) the composition releases at least 30% of the hydrophobic or a hydrophilic or water-miscible vehicle;
ii) the composition, in the form of a tablet, contains at least about 90% w/w of the oil-sorption material, and exhibits a disintegration time of at the most 60 minutes.
-
-
61-62. -62. (canceled)
Specification