Ready-for-complexation composition

• US 20060116335A1
• Filed: 11/26/2004
• Published: 06/01/2006
• Est. Priority Date: 11/26/2004
• Status: Abandoned Application

• Current Assignee: Lytone Enterprise, Inc.
• Original Assignee: Lytone Enterprise, Inc.
• Inventors: Chang, William T. H., Yeh, Wen Pin, Chen, James H. Y.
• Application Number:
  US10/998,257
• Publication Number:
  US 20060116335A1
• Time in Patent Office: Days
• US Class Current: 514/28
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 31/724 Cyclodextrins

Abstract

The invention relates to a ready-for-complexation (RFC) composition, comprising a polyene antimycotic and a cyclodextrin or the derivatives thereof. Also disclosed is a method of using the ready-for-complexation (RFC) composition of the invention to improve the solubility of polyene antimycotic.

Claims

1. A ready-for-complexation (RFC) composition, comprising a polyene antimycotic and a cyclodextrin or the derivatives thereof.

2. The ready-for-complexation composition of claim 1, wherein the polyene antimycotic is selected from the group consisting of natamycin, amphotericin B, aureofacin, candicidin, candidin, levorin, mycoheptin, nystatin, partricin A, partricin B, perimycin, pimaricin, polyfungin, rimocidin and trichomycin.

3. The ready-for-complexation composition of claim 2, wherein the polyene antimycotic is natamycin.

4. The ready-for-complexation composition of claim 1, wherein the cyclodextrin is selected from the group consisting of α

-cyclodextrin, β

-cyclodextrin and γ

-cyclodextrin.

5. The ready-for-complexation composition of claim 4, wherein the cyclodextrin is β

-cyclodextrin.

6. The ready-for-complexation composition of claim 1, wherein the cyclodextrin or the derivative is selected from the group consisting of hydroxypropyl derivatives of α

, β and

γ

-cyclodextrin, sulfoalkylether cyclodextrins, alkylated cyclodextrins and branched cyclodextrins.

7. The ready-for-complexation composition of claim 6, wherein the branched cyclodextrin is glucosyl-β

-cyclodextrin or maltosyl-β

-cyclodextrin.

8. The ready-for-complexation composition of claim 1, wherein the molar ration of the cyclodextrin to the polyene antimycotic ranges from 0.05:

1 to 5;

1.

9. The ready-for-complexation composition of claim 8, wherein the molar ration of the cyclodextrin to the polyene antimycotic ranges from 0.5:

1 to 4.;

1.

10. The ready-for-complexation composition of claim 9, wherein the molar ration of the cyclodextrin to the polyene antimycotic ranges from 1:

1 to 4.;

1.

11. A method of using a ready-for-complexation composition to improve the solubility of polyene antimycotics, comprising providing said ready-for-complexation composition and solving said composition in water or buffer solution to form a cyclodextrin-polyene antimycotic inclusion complex;

wherein said composition comprises polyene antimycotic and a cyclodextrin or the derivatives thereof.

12. The method of claim 11, wherein the concentration of the ready-for-complexation composition in the solution ranges from 1,000 to 30,000 ppm.

13. The method of claim 11, wherein the concentration of the ready-for-complexation composition in the solution ranges from 1,500 to 15,000 ppm.

14. A method of using a ready-for-complexation composition for postharvest treatment, comprising providing said composition and applying said composition to postharvest agricultural products, said composition comprises polyene antimycotic and a cyclodextrin or the derivatives thereof.

15. A method of using a ready-for-complexation composition in culture substrate against fungal infection, comprising providing said composition and applying said composition to a culture substrate, said composition comprises polyene antimycotic and a cyclodextrin or the derivatives thereof.