Regulators of the hedgehog pathway, compositions and uses related thereto
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Accused Products
Abstract
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
53 Citations
75 Claims
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1-42. -42. (canceled)
- 43. A method for regulating differentiation or proliferation of a cell, comprising administering to a patient a compound represented in the general formulas (I) (II), (III), (IV), or (V), or unsaturated forms thereof and/or seco-, nor- or homo-derivatives thereof:
- 54. A method for controlling the growth or development of pancreatic tissue, comprising contacting the tissue with a compound represented in the general formulas (I) (II), (III), (IV), or (V), or unsaturated forms thereof and/or seco-, nor- or homo-derivatives thereof:
- 65. A method for treating a hyperproliferative disorder, comprising administering to a patient a compound represented in the general formulas (I) (II), (III), (IV), or (V), or unsaturated forms thereof and/or seco-, nor- or homo-derivatives thereof:
Specification