Regeneration initiating cells
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions for treating hyperglycemia and pancreatic damage as well as stimulating the repair or regeneration of islet cells are disclosed.
37 Citations
40 Claims
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1-11. -11. (canceled)
- 12. A pharmaceutical composition for treating or preventing pancreatic damage comprising regeneration initiating cells in admixture with a pharmaceutically acceptable diluent, excipient or carrier, wherein the regeneration initiating cells are present in an effective amount to treat or prevent pancreatic damage.
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13. A pharmaceutical composition for stimulating the regeneration or repair of damaged islet cells comprising regeneration initiating cells in admixture with a pharmaceutically acceptable diluent, excipient or carrier, wherein the regeneration initiating cells are present in an effective amount to stimulate the regeneration or repair of damaged islet cells.
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14. A pharmaceutical composition for inducing the regeneration or repair of a damaged insulin secreting cell comprising a regeneration initiating cells in admixture with a pharmaceutically acceptable diluent, excipient or carrier, wherein the regeneration initiating cells are present in an effective amount to induce the regeneration or repair of a damaged insulin secreting cell.
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15. A pharmaceutical composition for treating hyperglycemia comprising regeneration initiating cells in admixture with a pharmaceutically acceptable diluent, excipient or carrier, wherein the regeneration initiating cells are present in an effective amount to treat hyperglycemia.
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20-22. -22. (canceled)
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23. A method of detecting the presence of a regeneration initiation cell in a sample comprising:
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(a) isolating low density mononuclear cells from the sample;
(b) transplanting the low density mononuclear cells into a recipient animal with tissue or organ damage; and
(c) determining whether or not the transplanted cells engraft the damage tissue or organ, wherein engraftment of the damaged tissue or organ indicates the presence of regeneration initiation cells in the sample. - View Dependent Claims (24, 25, 26, 27, 28)
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29. A method of treating or preventing pancreatic damage comprising administering an effective amount of isolated regeneration initiating cells to an animal in need thereof.
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30. A method of stimulating the regeneration or repair of damaged islet cells comprising administering an effective amount of isolated regeneration initiating cells to an animal in need thereof.
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31. A method of stimulating the regeneration or repair of damaged insulin secreting cells comprising administering an effective amount of a regeneration initiating cell to an animal in need thereof.
- 32. A method of treating hyperglycemia comprising administering an effective amount of a regeneration initiating cell to an animal in need thereof.
Specification