Apparatus and method for ascertaining and recording electrophysiological signals

• US 20060149139A1
• Filed: 11/21/2003
• Published: 07/06/2006
• Est. Priority Date: 11/21/2002
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Giorgio Bonmassar, John Bellliveau
• Inventors: Bonmassar, Glorgio, Belliveau, John W
• Application Number:
  US10/535,958
• Publication Number:
  US 20060149139A1
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 2562/066 in a matrix array
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/1102 Ballistocardiography
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4205 Evaluating swallowing
• CPC Class Codes: A61B 5/721 using a separate sensor to detect motion or using motion information derived from signals other than the physiological signal to be measured

Abstract

An arrangement and method for ascertaining and recording electrophysiological signals associated with a subject are provided. In particular, first (or motion) data associated with a movement of the subject from one or more motion sensors can be received. Such movement may include a head movement by the subject, swallowing by the subject, etc. The first data also can include noise associated with a blood flow motion within the subject, noise associated with a ballistocardiac motion within the subject, etc. Second data associated with intrinsic voltages measured may also be received from the subject. Then, output or result data can be calculated based on the first motion data and the second data. The output (or result data) is preferably associated with the electrophysiological signal. In an exemplary embodiment, a continuous, real time display of electrophysiological signals that is associated with the output data can be generated.

Claims

1. An arrangement for ascertaining and recording an electrophysiological signal associated with a subject, comprising:

a processing system which, when executing a filtering program, is adapted to;

receive first data associated with a movement of the subject from at least one motion sensor,

receive second data associated with at least one intrinsic voltage measured from the subject, and

calculate result data based on the first data and the second data, wherein the result data is associated with the electrophysiological signal.

2. The arrangement of claim 1, wherein the first data is motion data for at least one of a head movement and a swallowing motion by the subject.

3. The arrangement of claim 1, wherein the filtering program comprises a filter routine.

4. The arrangement of claim 3, wherein the filter routine is adapted to receive and process the motion data.

5. The arrangement of claim 4, wherein the first data is an output of the filter routine, and wherein the result data is obtained by subtracting the first data from the second data.

6. The arrangement of claim 5, wherein the filter routine is an adaptive filter routine.

7. The arrangement of claim 6, wherein the adaptive filter routine is a Kalman-type adaptive filter routine.

8. The arrangement of claim 1, further comprising:

a plurality of electrodes positioned on at least one portion of the subject; and

an analog to digital (A/D) converter coupled to each of the electrodes, wherein the A/D converter is adapted to measure the at least one intrinsic voltage and transmit the first data to the processing system.

9. The arrangement of claim 8, wherein the A/D converter is a 24 bit A/D converter.

10. The arrangement of claim 8, wherein the A/D converter is positioned within a magnetic resonance imaging environment, and wherein the processing system is positioned outside the magnetic resonance imaging environment.

11. The arrangement of claim 8, wherein the at least one motion sensor is a piezoelectric transducer positioned on a temporal artery of the subject, and wherein each of the electrodes is positioned on a scalp portion of the subject.

12. The arrangement of claim 1, wherein the at least one motion sensor includes at least one portion which is filled with an acoustic dampener that has silicon.

13. The arrangement of claim 1, wherein the first data is further associated with at least one of a ballistocardiac motion within the subject and a blood flow motion within the subject.

14. The arrangement of claim 13, wherein the ballistocardiac motion includes a cardiac pulsation.

15. The arrangement of claim 1, wherein the processing system is further adapted to generate a continuous, real time display of the electrophysiological signals associated with the result data.

16. The arrangement of claim 1, wherein the at least one motion sensor has an output which is modulated by an adaptive trigger.

17. The arrangement of claim 1, further comprising:

a plurality of electrodes positioned on at least one portion of the subject;

an amplifier coupled to each of the at least one motion sensor and the plurality of electrodes;

an RF filter coupled to the amplifier; and

an analog to digital (A/D) converter coupled to the RF filter, wherein the A/D converter is adapted to measure the at least one intrinsic voltage and transmit the first data to the processing system.

18. The arrangement of claim 17, wherein the RF filter is coupled to the A/D converter via a programable, signal conditioning circuit.

19. The arrangement of claim 18, wherein the at least one motion sensor is coupled to the RF filter, such that the at least one motion sensor is coupled to the processing system via the amplifier, the RF filter, the signal conditioning circuit, and the A/D converter.

20. The arrangement of claim 19, further comprising an EEG system, wherein the EEG system comprises the signal conditioning circuit, the A/D converter, and a digital signal processor, and wherein the digital signal processor comprises a first clock.

21. The arrangement of claim 20, further comprising a MRI system comprising a second clock, wherein an output of the MRI system is connected to the digital signal processor via a direct digital synthesizer, and wherein the direct digital synthesizer is adapted to synchronize the second clock with the first clock.

22. The arrangement of claim 21, further comprising a stimulation system for stimulating the subject.

23. A method of ascertaining and recording electrophysiological signals associated with a subject, comprising the steps of:

receiving first data associated with a movement of the subject from at least one motion sensor;

receiving second data associated with at least one intrinsic voltage measured from the subject; and

calculating result data based on the first motion data and the second data using a filtering routine, wherein the result data is associated with the electrophysiological signal.

24. The method of claim 23, wherein the first data is motion data for at least one of a head movement and a swallowing motion by the subject.

25. The method claim 23, wherein a processing system is adapted to receive the motion data associated with the movement of the subject, and wherein the filtering routine adapts a processing system to receive the second data.

26. The method of claim 25, wherein the first data is an output of the filter routine, and wherein the calculating step comprises subtracting the first data from the second data.

27. The method of claim 23, wherein at least one portion of the at least one motion sensor includes an acoustic dampener comprising silicon.

28. The method of claim 23, wherein the filter routine is an adaptive filter routine.

29. The method of claim 28, wherein the adaptive filter routine is a Kalman-type adaptive filter routine.

30. The method of claim 23, further comprising the steps of:

positioning a plurality of electrodes on at least one portion of the subject;

measuring the at least one intrinsic voltage using an analog to digital (A/D) converter; and

transmitting the first data to the processing system.

31. The method of claim 30, wherein the A/D converter is a 24 bit A/D converter.

32. The method of claim 30, wherein the A/D converter is positioned within a magnetic resonance imaging environment, and wherein the processing system is positioned outside the magnetic resonance imaging environment.

33. The method of claim 30, wherein the at least one motion sensor is a piezoelectric transducer positioned on a temporal artery of the subject, and wherein each of the electrodes are positioned on the scalp of the subject.

34. The method of claim 23, wherein the first data is further associated with at least one of a ballistocardiac motion within the subject and a blood flow motion within the subject.

35. The method of claim 34, wherein the ballistocardiac motion includes a cardiac pulsation.

36. The method of claim 23, further comprising the step of generating a continuous, real time display of the electrophysiological signals associated with the result data.

37. The method of claim 23, further comprising the step of modulating an output of the at least one motion sensor.