Apparatus and method for measuring reaction result of samples on biosensor

• US 20060163086A1
• Filed: 10/04/2002
• Published: 07/27/2006
• Est. Priority Date: 09/30/2002
• Status: Active Grant

• Current Assignee: Osang Healthcare Co., Ltd.
• Original Assignee: INFOPIA CO., LTD
• Inventors: Lee, Sung-Dong, Lee, Heon-Kwon, Bae, Byung-Woo, Kim, Won-Dong, Song, Jung-Shik, Yoo, Jin-A
• Granted Patent: US 7,678,261 B2
• Time in Patent Office: Days
• US Class Current: 205/775
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Disclosed are an apparatus and a method for determining whether or not a biosensor comprising two working electrodes and one reference electrode is well manufactured, and for rapidly and accurately quantifying a specific substance contained in a biological sample. The method comprises the steps of: sequentially supplying the respective working electrodes with power supply voltage; sequentially detecting the amounts of current flowing in the respective working electrodes by virtue of the supplied power supply voltage; re-supplying the two working electrodes with power supply voltage after a predetermined time to redetect the amounts of current flowing in the respective working electrodes; reading concentrations corresponding to the amounts of current detected from a memory, and calculating an average value from the read concentrations; and checking whether or not the concentrations read from memory are within a predetermined critical range to display an error message or the calculated average value.

Claims

1. A method for measuring reaction results of a sample using a biosensor comprising two working electrodes and one reference electrode, comprising the steps of:

sequentially supplying the respective working electrodes with power supply voltage;

sequentially detecting the amounts of current flowing in the respective working electrodes by virtue of the supplied power supply voltage;

re-supplying the two working electrodes with power supply voltage to redetect the amounts of current flowing in the respective working electrodes;

reading concentrations corresponding to the amounts of current detected from a memory, and calculating an average value from the read concentrations; and

checking whether or not the concentrations read from the memory are within a predetermined critical range to display an error message or the calculated average value.

2. The method for measuring reaction results of a sample as set forth in claim 1, further comprising the steps of:

determining whether or not an error is generated, by measuring a time interval from when the amount of current flowing in the first working electrode is detected to when the amount of current flowing in the second working electrode is detected and by measuring the respective amounts of current detected; and

displaying the generated error.

3. An apparatus for measuring reaction results of a sample using a biosensor comprising two working electrodes and one reference electrode, comprising:

one or more operational amplifiers for detecting the amounts of current flowing in the respective working electrodes and outputting the amounts of current as voltage values, non-inverting terminals of the respective operational amplifiers being connected to a voltage source, and inverting terminals of the respective operational amplifiers being connected to one side of each of switches;

a second switch for grounding the reference electrode of the biosensor;

a third switch for grounding one of the working electrodes of the biosensor;

a display for displaying reaction results of the sample and an error message; and

a microprocessor, the microprocessor controlling the switches to supply the two working electrodes with power supply voltage, examining whether or not the sample reaches the electrodes, controlling the switches to resupply the two working electrodes with power supply voltage, reading the concentrations corresponding to detected voltage values, calculating an average value from the read concentrations, comparing the average value with the respective concentrations, and displaying an error message or the calculated average value.