Handheld raman blood analyzer
First Claim
1. A system for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
- a sampling port for receiving a sample of blood on a target region, a light source for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array and calculating information about an analyte within the blood sample.
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Abstract
Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold sol-gel to provide surface enhanced Raman scattering. A light source irradiates the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation that is separated into different wavelength components by a dispersion element. A detection array detects a least some of the wavelength components of the scattered light and provides data to a processor for processing the data. The results of the processed data are displayed on a screen to inform a user about an analyte within the blood sample.
258 Citations
20 Claims
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1. A system for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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a sampling port for receiving a sample of blood on a target region, a light source for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array and calculating information about an analyte within the blood sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18, 19)
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16. A system for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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a strip for receiving a sample of blood on a target region, the target region including a material to provide surface enhanced Raman scattering;
a laser for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array and calculating glucose concentration and information about at least one other analyte within the blood sample.
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20. A method for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy comprising:
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providing a disposable strip for receiving a sample of blood on a target region;
depositing a sample of blood on the target region of the disposable strip;
irradiating the target region with a laser to produce a Raman spectrum consisting of scattered electromagnetic radiation;
receiving and separating the scattered radiation into different wavelength components using a low resolution dispersion element;
detecting at least some of the wavelength components of the scattered light using a detection array;
processing data from the detector array and calculating information about an analyte within the blood sample with a processor; and
displaying information related to the analyte detected within the blood sample on a screen.
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Specification