EEG feedback controlled sound therapy for tinnitus

• US 20060167376A1
• Filed: 11/30/2005
• Published: 07/27/2006
• Est. Priority Date: 02/05/2001
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Viirre, Erik, Hestenes, John D., Pineda, Jaime A., Vankov, Andrey
• Granted Patent: US 7,572,234 B2
• Time in Patent Office: Days
• US Class Current: 600/559
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61F 11/00 Methods or devices for treatment of the ears or hearing sense implantable prostheses that substitute or replace internal ear parts, e.g. ear-drums, A61F2/18; methods or devices to cause a change in the state of auditory consciousness A61M21/00; electrotherapy applying electrical stimulation of the auditory system, or circuits therefor A61N1/36; radiotherapy using optical stimulation of the auditory system A61N5/06; electro-acoustic hearing aids H04R25/00; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand headwear, e.g. caps or helmets, with means for protecting the ears A42B1/0188, A42B3/16

Abstract

An automated method for treating tinnitus by habituation through use of neurological feedback, comprising the steps of connecting a subject through a set of attached headphones to an electronic sound player that is connected to a PC workstation presenting sound examples by software to the subject who can refine them by manipulating a series of controllers on the player, making an electronic recording of the sound in a digital music format, storing the recording in the computer, transferring a copy of the electronic sound file to the subject'"'"'s electronic music player, generating an EEC signature of the subject'"'"'s brain activity in response to the presented sound, sound using the customized sound to stimulate the auditory system while the brain activity is recorded, wherein the computer continuously monitors for the feedback signatures and drives the sound stimuli appropriately.

Claims

1-9. -9. (canceled)

10. An objective method for diagnosing tinnitus comprising:

(a) determining a perceived tinnitus tone pitch of a subject;

(b) recording an auditory evoked potential of the subject to the tinnitus tone pitch and to at least one other tone pitch, wherein the tinnitus tone pitch and the at least one other tone pitch are played to the subject at a first intensity;

(c) repeating step (b) with at least a second intensity;

(d) calculating the slope of augmenting/reducing (AR) response of N100 for the tinnitus pitch and the at least one other tone pitch, wherein an increase in the slope of the AR response to the tinnitus tone pitch is indicative of tinnitus.

11. The method of claim 10, wherein determining the perceived tinnitus tone pitch of the subject comprises:

presenting the subject a continuous audible tone of varying pitch;

determining which pitch is perceived by the subject as the tinnitus tone pitch, thereby determining the perceived tinnitus tone pitch of the subject.

12. The method of claim 11, wherein the continuous audible tone is a pure sine tone.

13. The method of claim 12, wherein the pure sine tone is generated by a function generator.

14. The method of claim 13, wherein the function generator comprises a programmable logarithmic amplifier that is controlled in real time by a stimulus presentation and data collection program to set the intensity of each tone.

15. The method of claim 10, wherein determining the perceived tinnitus tone pitch of the subject is performed using audiometrics.

16. The method of claim 10, further comprising the step of determining a hearing threshold of the subject to the perceived tinnitus tone pitch of step (a).

17. The method of claim 16, wherein the first intensity is 30 dB above the hearing threshold of the subject to the perceived tinnitus tone pitch.

18. The method of claim 10, wherein the subject perceives two tinnitus tone pitches that are one octave or two octaves apart.

19. The method of claim 10, wherein the at least one other tone pitch comprises 80 tone pitches.

20. The method of claim 10, wherein the at least a second intensity comprises 5 intensities.

21. The method of claim 10, wherein the tinnitus tone pitch is near 4kHz, thereby diagnosing the tinnitus as noise-induced tinnitus.

22. The method of claim 10, wherein an increase in the slope of the AR response to the tinnitus tone pitch is indicative of tinnitus-related activity in the auditory cortex.

23. An EEG marker of tinnitus suitable for diagnosing the presence of tinnitus in a subject, comprising;

a replica of an experience of a subject to sound, wherein the sound includes a sound that is annoying to the subject; and

a measure of an EEG response of the subject to increasing intensity of the sound, wherein the peak amplitude of an N100 component can be determined from the measure of the EEG.

24. The method of claim 23, wherein the measure of the EEG response of the subject comprises auditory potentials evoked in response to the sound that is annoying to the subject and to at least one other sound.

25. The method of claim 24, wherein the at least one other sound comprises a 1, 2, or 4 kHz tone.

26. The method of claim 23, wherein the measure of the EEG response of the subject is corrected for artifacts.

27. The method of claim 26, wherein the artifacts comprise eye movement artifacts.

28. The method of claim 23, wherein a P200 component and a N100/P200 complex can be determined from the measure of the EEG.

29. The method of claim 23, wherein electrode sites for the measure of the EEG are referenced to linked mastoids.