Control of drug release by transient modification of local microenvironments
First Claim
1. A method for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device comprising:
- providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.
114 Citations
40 Claims
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1. A method for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device comprising:
providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable medical device for the storage and controlled release of a drug formulation comprising:
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a body portion;
at least one reservoir located in at least one surface of the body portion and having at least one release opening;
at least one drug formulation, which comprises at least one drug, disposed within the at least one reservoir; and
a release-modifying agent disposed within the at least one of the reservoirs or within one or more second reservoirs. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification