Externally enhanced ultrasonic therapy

• US 20060173387A1
• Filed: 12/09/2005
• Published: 08/03/2006
• Est. Priority Date: 12/10/2004
• Status: Abandoned Application

• Current Assignee: EKOS Corporation (Boston Scientific Corporation)
• Original Assignee: EKOS Corporation (Boston Scientific Corporation)
• Inventors: Villar, Francisco S., Genstler, Curtis, Hansmann, Douglas
• Application Number:
  US11/297,979
• Publication Number:
  US 20060173387A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2205/02 Head
• CPC Class Codes: A61H 2205/10 Leg
• CPC Class Codes: A61H 23/0245 with ultrasonic transducers, e.g. piezoelectric
• CPC Class Codes: A61H 39/007 Stimulation by mechanical vibrations, e.g. ultrasonic
• CPC Class Codes: A61H 7/006 Helmets for head-massage baths for the head A61H35/008; washing, rinsing, drying A45D
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

In one embodiment, a method for treating a vascular occlusion in a patient'"'"'s body comprises exposing the vascular occlusion to an external ultrasonic energy field that is generated outside the patient'"'"'s body. The method further comprises positioning an ultrasound radiating member in the patient'"'"'s body in the vicinity of the vascular occlusion. The method further comprises exposing the vascular occlusion to an internal ultrasonic energy field that is generated by the ultrasound radiating member. The method further comprises using the ultrasound radiating member to detect a first characteristic of the external ultrasonic energy field. The method further comprises adjusting a second characteristic of the external ultrasonic energy field based on the detected first characteristic of the external ultrasonic energy field.

Claims

1. A method for treating a vascular occlusion in a patient'"'"'s body, the method comprising:

exposing the vascular occlusion to an external ultrasonic energy field that is generated outside the patient'"'"'s body;

positioning an ultrasound radiating member in the patient'"'"'s body in the vicinity of the vascular occlusion;

exposing the vascular occlusion to an internal ultrasonic energy field that is generated by the ultrasound radiating member;

using the ultrasound radiating member to detect a first characteristic of the external ultrasonic energy field; and

adjusting a second characteristic of the external ultrasonic energy field based on the detected first characteristic of the external ultrasonic energy field.

2. The method of claim 1, wherein the ultrasound radiating member is used to detect the first characteristic before the vascular occlusion is exposed to the internal ultrasonic energy field.

3. The method of claim 1, wherein the internal ultrasonic energy field is generated by applying a voltage difference to the ultrasound radiating member.

4. The method of claim 1, wherein the external ultrasonic energy field is generated by an array of extracorporeal ultrasound radiating members positioned within a housing.

5. The method of claim 1, wherein the ultrasound radiating member is positioned on a guidewire that is used in the delivery of a catheter to the treatment site, wherein the catheter includes a fluid delivery lumen adapted to deliver a therapeutic compound to the vascular occlusion.

6. The method of claim 1, wherein the ultrasound radiating member is positioned in the patient'"'"'s body after the vascular occlusion is exposed to the external ultrasonic energy field.

7. The method of claim 1, wherein the ultrasound radiating member is positioned on a catheter that includes a fluid delivery lumen adapted to deliver a therapeutic compound to the vascular occlusion.

8. The method of claim 1, further comprising delivering a therapeutic compound from a catheter to the vascular occlusion during exposure of the vascular occlusion to at least one of the external ultrasonic energy field and the internal ultrasonic energy field.

9. The method of claim 1, wherein the first characteristic of the external ultrasonic energy field is power delivered to the vascular occlusion.

10. The method of claim 1, wherein the second characteristic of the external ultrasonic energy field is selected from the group consisting of field position, field orientation, pulse width and duty cycle.

11. A system for treating a vascular occlusion within a patient'"'"'s vasculature, the system comprising:

an extracorporeal ultrasound radiating member positioned within a housing;

an internal ultrasound radiating member coupled to an elongate body that is configured to be passed through the patient'"'"'s vasculature to the vascular occlusion; and

a control system that is configured to (a) supply an extracorporeal drive signal to the extracorporeal ultrasound radiating member and an internal drive signal to the internal ultrasound radiating member, and (b) receive a microphone signal from the internal ultrasound radiating member, wherein the control system is configured to adjust the extracorporeal drive signal based on the microphone signal.

12. The system of claim 11, wherein the elongate body is selected from the group consisting of a guidewire and a catheter body.

13. The system of claim 11, wherein the elongate body is a catheter having a fluid delivery lumen configured to deliver a therapeutic compound to the vascular occlusion.

14. The system of claim 11, further comprising an interface configured to be coupled to the housing, wherein the interface comprises an acoustically transmissive material.

15. The system of claim 11, wherein a plurality of extracorporeal ultrasound radiating members are positioned within the housing.

16. The system of claim 11, further comprising a user interface configured to display information related to the microphone signal.

17. The system of claim 11, further comprising a temperature sensor coupled to the elongate body, wherein the temperature sensor is configured to provide a temperature signal to the control system.

18. A method comprising:

positioning an ultrasound radiating member in a patient'"'"'s vasculature in the vicinity of a vascular occlusion;

irradiating the vascular occlusion with ultrasonic energy generated by a first ultrasonic energy field that is generated by the ultrasound radiating member;

delivering a therapeutic compound to the vascular occlusion; and

exposing a portion of the patient'"'"'s vasculature that is downstream with respect to the vascular occlusion to a second ultrasonic energy field that is generated by an extracorporeal ultrasound radiating member.

19. The method of claim 18, wherein the ultrasound radiating member comprises a piezoelectric element.

20. The method of claim 18, wherein the ultrasound radiating member is coupled to a catheter that includes a fluid delivery lumen that is used to deliver the therapeutic compound to the vascular occlusion.

21. The method of claim 18, wherein the ultrasound radiating member is positioned upstream with respect to the vascular occlusion.

22. The method of claim 18, wherein the ultrasound radiating member is positioned within the vascular occlusion.

23. The method of claim 18, wherein the ultrasound radiating member is coupled to a guidewire used to deliver a catheter to the treatment site, wherein the catheter include a fluid delivery lumen hat is used to deliver the therapeutic compound to the treatment site.

24. The method of claim 18, further comprising evaluating a characteristic of the second ultrasonic energy field using the ultrasound radiating member.