Coated microprojections having reduced variability and method for producing same
First Claim
1. A transdermal delivery device comprising a microprojection member having at least one stratum corneum-piercing microprojection, wherein said microprojection has a length extending from a distal tip to a proximal end, wherein said microprojection has a maximum width located in the range of approximately 25% to 75% of the length of said microprojection measured from said distal tip of said microprojection, and wherein said microprojection has a minimum width proximal to said maximum width.
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Abstract
The present invention provides methods and devices for reducing the coating variability of a transdermal microprojection delivery device. The device has one or more stratum corneum-piercing microprojections, wherein each microprojection has a maximum width located in the range of approximately 25% to 75% of the length of the microprojection and wherein the microprojection has a minimum width proximal to the maximum width. Preferably, the microprojection has a coating of a biologically active agent that at a minimum extends to at least approximately 75% of the distance from the distal tip to a location corresponding to the maximum width and at most extends up to approximately 90% of the length of the microprojection.
55 Citations
17 Claims
- 1. A transdermal delivery device comprising a microprojection member having at least one stratum corneum-piercing microprojection, wherein said microprojection has a length extending from a distal tip to a proximal end, wherein said microprojection has a maximum width located in the range of approximately 25% to 75% of the length of said microprojection measured from said distal tip of said microprojection, and wherein said microprojection has a minimum width proximal to said maximum width.
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14. A method of applying a coating of a biologically active agent to a transdermal delivery device comprising the steps of providing a microprojection member having at least one stratum corneum-piercing microprojection, wherein said microprojection has a length extending from a distal tip to a proximal end, wherein said microprojection has a maximum width located in the range of approximately 25% to 75% of the length of said microprojection measured from said distal tip of said microprojection, and wherein said microprojection has a minimum width proximal to said maximum width;
- applying a formulation of said biologically active agent to said microprojection; and
drying said formulation to form a coating. - View Dependent Claims (15, 16, 17)
- applying a formulation of said biologically active agent to said microprojection; and
Specification