Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
First Claim
1. An internal medical device comprising:
- (a) electrodes that are adapted to have tissue of a subject positioned between them upon deployment of said medical device within said subject, (b) a power source adapted to apply a voltage across said electrodes, thereby generating an electric field having a vector that is directed into said tissue, and (c) a therapeutic agent source adapted to introduce a therapeutic agent into said electric field.
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Accused Products
Abstract
The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
238 Citations
54 Claims
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1. An internal medical device comprising:
- (a) electrodes that are adapted to have tissue of a subject positioned between them upon deployment of said medical device within said subject, (b) a power source adapted to apply a voltage across said electrodes, thereby generating an electric field having a vector that is directed into said tissue, and (c) a therapeutic agent source adapted to introduce a therapeutic agent into said electric field.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An internal drug delivery device comprising:
- (a) an ion-conductive polymeric region comprising a polymer and a charged therapeutic agent;
(b) electrodes and (c) a source of electrical power for applying a voltage across said electrodes. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
- (a) an ion-conductive polymeric region comprising a polymer and a charged therapeutic agent;
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46. An internal drug delivery device comprising:
- (a) a polymeric region comprising an electrically conductive polymer and a charged therapeutic agent;
(b) electrodes and (c) a source of electrical power for applying a voltage across said electrodes, said voltage being sufficient to cause electroporation in tissue adjacent to said device. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54)
- (a) a polymeric region comprising an electrically conductive polymer and a charged therapeutic agent;
Specification