Novel biomaterial drug delivery and surface modification compositions
First Claim
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1. A blend comprising a first polymer made at least in part from a polyoxyalkylene copolymer in combination with a second component selected from the group consisting of polymers and oligomers.
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Abstract
Compositions are provided which include a polymer made at least in part from a polyoxyalkylene copolymer, such as a poloxamer. The polymer may be combined with a second component to form a blend or emulsion. The resulting composition may be utilized to form medical devices, drug delivery devices, or coatings for other medical devices.
61 Citations
41 Claims
- 1. A blend comprising a first polymer made at least in part from a polyoxyalkylene copolymer in combination with a second component selected from the group consisting of polymers and oligomers.
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4. A blend comprising:
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a bioabsorbable terpolymer comprising about 30 to about 50 weight percent of a polyoxyalkylene copolymer, about 40 to about 50 weight percent epsilon-caprolactone derived units, the balance of the copolymer being derived from at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
a polymer derived from two or more monomers selected from the group consisting of lactide, glycolide, lactic acid, lactones, glycolic acid, carbonates, orthoesters, absorbable urethanes, and absorbable nylons. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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- 20. An emulsion comprising a first polymer made at least in part from a polyoxyalkylene copolymer in combination with a second component selected from the group consisting of polymers and oligomers.
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23. An emulsion comprising:
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a bioabsorbable terpolymer comprising about 30 to about 50 weight percent of a polyoxyalkylene copolymer, about 40 to about 50 weight percent epsilon-caprolactone derived units, the balance of the copolymer being derived from at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
a polymer derived from two or more monomers selected from the group consisting of lactide, glycolide, lactic acid, lactones, glycolic acid, carbonates, orthoesters, absorbable urethanes, and absorbable nylons. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A surgical suture coated with a composition comprising:
- an effective antimicrobial amount of a terpolymer having a polyoxyalkylene copolymer component, a plurality of epsilon-caprolactone derived units, and a plurality of repeating units derived from glycolide.
- View Dependent Claims (40, 41)
Specification