Biointerface membranes incorporating bioactive agents

  • US 20060198864A1
  • Filed: 05/03/2006
  • Published: 09/07/2006
  • Est. Priority Date: 05/21/2003
  • Status: Abandoned Application
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First Claim
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1. A method of measuring an analyte concentration, the method comprising the step of:

  • measuring a signal from an implantable device, wherein the signal is indicative of an analyte concentration, the implantable device comprising a housing comprising electronic circuitry, and at least one sensing region operably connected to the electronic circuitry of the housing, wherein the sensing region comprising a biointerface membrane and is configured to be implanted in a tissue of a host, the biointerface membrane comprising a first domain distal to the implantable device, wherein the first domain comprises an open-cell configuration, the biointerface membrane comprising a second domain proximal to the implantable device, wherein the second domain is substantially impermeable to cells or cell processes, and wherein the biointerface membrane comprises a bioactive agent incorporated into the biointerface membrane which is delivered to the tissue of the host.

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