Method and apparatus for calibrating an analyte detection system with a calibration sample
First Claim
1. A fluid sampling and analysis system comprising:
- a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid of a patient;
a sample analysis chamber accessible by said fluid handling network;
a pump unit in operative engagement with said fluid handling network, said pump unit having;
an infusion mode in which said pump unit is operable to deliver infusion fluid to said patient through said patient end, a sample draw mode in which said pump unit is operable to draw a sample of bodily fluid from said patient through said patient end, and provide a portion of said sample to said sample analysis chamber, and an optical calibration mode in which said pump unit is operable to supply calibration fluid to said sample analysis chamber;
a spectroscopic analyzer configured to obtain spectra of the contents of said sample analysis chamber;
a processor in communication with or incorporated into said spectroscopic analyzer; and
stored program instructions executable by said processor to obtain a measurement of one or more analytes in the portion of said sample from said spectra.
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Accused Products
Abstract
A fluid sampling and analysis system. The system comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid of a patient; a sample analysis chamber accessible by the fluid handling network; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end; a sample draw mode in which the pump unit is operable to draw a sample of bodily fluid from the patient through the patient end, and provide a portion of the sample to the sample analysis chamber; and an optical calibration mode in which the pump unit is operable to supply calibration fluid to the sample analysis chamber. The system further comprises a spectroscopic analyzer configured to obtain spectra of the contents of the sample analysis chamber; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain a measurement of one or more analytes in the portion of the sample from the spectra.
206 Citations
24 Claims
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1. A fluid sampling and analysis system comprising:
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a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid of a patient;
a sample analysis chamber accessible by said fluid handling network;
a pump unit in operative engagement with said fluid handling network, said pump unit having;
an infusion mode in which said pump unit is operable to deliver infusion fluid to said patient through said patient end, a sample draw mode in which said pump unit is operable to draw a sample of bodily fluid from said patient through said patient end, and provide a portion of said sample to said sample analysis chamber, and an optical calibration mode in which said pump unit is operable to supply calibration fluid to said sample analysis chamber;
a spectroscopic analyzer configured to obtain spectra of the contents of said sample analysis chamber;
a processor in communication with or incorporated into said spectroscopic analyzer; and
stored program instructions executable by said processor to obtain a measurement of one or more analytes in the portion of said sample from said spectra. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of optically calibrating an analysis system comprising:
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providing a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient, a sample analysis chamber accessible by said fluid handling network, and a spectroscopic analyzer positioned to analyze the contents of said sample analysis chamber;
providing a calibration fluid to the sample analysis chamber;
determining a calibration of the sample analysis chamber provided with the calibration fluid;
providing at least a portion of a bodily fluid to the spectroscopic analyzer;
obtaining a spectra of said portion of bodily fluid; and
determining the concentration of at least one analyte of said sample from the obtained spectra and the calibration. - View Dependent Claims (22)
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23. An apparatus comprising:
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means for providing a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient, a sample analysis chamber accessible by said fluid handling network, and a spectroscopic analyzer positioned to analyze the contents of said sample analysis chamber;
means for providing a calibration fluid to the sample analysis chamber;
means for determining a calibration of the sample analysis chamber provided with the calibration fluid;
means for providing at least a portion of a bodily fluid to the spectroscopic analyzer;
means for obtaining a spectra of said portion of bodily fluid; and
means for determining the concentration of at least one analyte of said sample from the obtained spectra and the calibration. - View Dependent Claims (24)
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Specification