Intra-bronchial obstruction device that provides a medicant intra-bronchially to the patient

• US 20060206147A1
• Filed: 05/03/2006
• Published: 09/14/2006
• Est. Priority Date: 02/21/2002
• Status: Abandoned Application

• Current Assignee: Gyrus ACMI, Inc. (Olympus Corporation)
• Original Assignee: Gyrus ACMI, Inc. (Olympus Corporation)
• Inventors: Gonzales, Hugo X., DeVore, Lauri J., Shea, Richard O., Springmeyer, Steven Chase, Wang, John H.
• Application Number:
  US11/418,541
• Publication Number:
  US 20060206147A1
• Time in Patent Office: Days
• US Class Current: 606/213
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12159 Solid plugs; being solid before insertion
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2017/22067 Blocking; Occlusion A61B2017/22054 takes precedence
• CPC Class Codes: A61B 2017/242 for bronchial passages
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61M 1/78 Means for preventing overflow or contamination of the pumping systems combined with drainage containers A61M1/60
• CPC Class Codes: A61M 2025/0076 Unidirectional valves
• CPC Class Codes: A61M 2210/1035 Bronchi
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61N 2005/1021 Radioactive fluid
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

An intra-bronchial device provides a medicant intra-bronchially. The medicant may be used for controlling biological interaction of an intra-bronchial obstruction device with the patient, to treat a disease or condition of the lungs such as pneumonia or lung cancer, or to treat a systemic disease or condition. The medicant is provided by associating a medicant with the intra-bronchial device, either before, at the time of placement, or after placement. The medicant may overlie at least a portion of the intra-bronchial device, be absorbed into at least a portion of the intra-bronchial device, or be carried in a chamber. The intra-bronchial device may further include an absorptive member, and the medicant is absorbed by the absorptive member.

Claims

1. A method of treating a lung of a patient, the method comprising:

providing an intra-bronchial device configured to be implanted in an air passageway of a lung, the intra-bronchial device carrying a medicant; and

placing the intra-bronchial device in the air passageway so that said intra-bronchial device substantially prevents expiratory airflow and permits inspiratory airflow.

2. The method of claim 1, further comprising releasing the medicant such that said medicant is substantially prevented from moving past the intra-bronchial device.

3. The method of claim 2, wherein the medicant is released in a region of the lung that is located distally of the intra-bronchial device, and the medicant is substantially prevented from moving proximally past the intra-bronchial device.

4. The method of claim 1, wherein placing the intra-bronchial device in the air passageway permits inspiratory airflow centrally through said intra-bronchial device.

5. The method of claim 1, wherein placing the intra-bronchial device in the air passageway permits inspiratory airflow between said intra-bronchial device and a wall defining said air passageway of the lung.

6. The method of claim 1, further comprising implanting the intra-bronchial device in the air passageway for a sufficient length of time to release the medicant.

7. The method of claim 1, further comprising securing the intra-bronchial device in the air passageway with at least one anchor that engages a wall of said air passageway.

8. The method of claim 7, wherein the at least one anchor carries the medicant.

9. The method of claim 7, wherein the medicant encourages a biological reaction to enhance retention of the at least one anchor when said medicant is released.

10. The method of claim 7, wherein the intra-bronchial device comprises a plurality of anchors configured to secure the intra-bronchial device in the air passageway.

11. The method of claim 1, wherein the medicant comprises at least one of an antimicrobial agent, antibiotic agent or antibacterial agent, antiviral agent, anthelmintic agent, anti-inflammatory agent, antineoplastic agent, antioxidant agent, biological reaction inhibitor, botulinum toxin agent, chemotherapy agent, diagnostic agent, gene therapy agent, hormonal agent, mucolytic agent, radioprotective agent, radioactive agent, tissue growth inhibitor, tissue growth enhancer, and vasoactive agent

12. A method of treating a lung of a patient, the method comprising:

moving an intra-bronchial device through an air passageway of a lung, a medicant being associated with the intra-bronchial device;

positioning the intra-bronchial device in the air passageway; and

implanting the intra-bronchial device so that said intra-bronchial device substantially prevents expiratory airflow and permits inspiratory airflow.

13. The method of claim 12, wherein the medicant comprises at least one of an antimicrobial agent, antibiotic agent or antibacterial agent, antiviral agent, anthelmintic agent, anti-inflammatory agent, antineoplastic agent, antioxidant agent, biological reaction inhibitor, botulinum toxin agent, chemotherapy agent, diagnostic agent, gene therapy agent, hormonal agent, mucolytic agent, radioprotective agent, radioactive agent, tissue growth inhibitor, tissue growth enhancer, and vasoactive agent.

14. The method of claim 12, further comprising securing the intra-bronchial device in the air passageway with at least one deployable anchor carried by said intra-bronchial device.

15. The method of claim 12, wherein the implanting of the intra-bronchial device permits releasing of the medicant.

16. The method of claim 12, wherein the medicant is positioned on a movable portion of the intra-bronchial device to aid in the release of said medicant when the movable portion is moved from a first position for substantially preventing expiratory airflow and second position for permitting inspiratory airflow.

17. The method of claim 16, wherein the movable portion forms at least a portion of a one-way valve.

18. The method of claim 12, further comprising releasing the medicant such that the released medicant is substantially prevented from moving past the intra-bronchial device.