Systems and Methods for Treating Disorders of the Central Nervous System by Modulation of Brain Networks
First Claim
1. A method of treating at least one symptom of a brain disorder which comprises modulating at least two regions of a brain network according to a treatment protocol, said brain network having at least one brain region associated the symptom for which treatment is sought.
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Abstract
The present invention involves methods and systems for treatment of brain disorders using neuromodulation that is provided to modulate structures of brain networks. Treatment occurs using electrical, optical, magnetic, and/or chemical stimulation of one or more brain networks associated with a brain disorder. The methods involve using a brain modulation system (BMS) to increase, decrease, or otherwise modulate characteristics of the regions of the network, such as relative levels of electrical activity or neurotransmitter levels. Treatment can be initiated and adjusted based upon evaluation of functional neuroimaging data for the network and brain network modeling. Linking rules may guide in adjusting the treatment protocol used to provide neuromodulation of multiple regions of a brain network. Novel methods are described for addressing issues of compensation, adaptation, and unintentional modulation due to indirect stimulation that can arise due to connectivity between structures within brain networks.
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21 Claims
- 1. A method of treating at least one symptom of a brain disorder which comprises modulating at least two regions of a brain network according to a treatment protocol, said brain network having at least one brain region associated the symptom for which treatment is sought.
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16. A system of treating a brain disorder comprising a least one brain modulation device having at least two stimulators which are located in order to stimulate at least two areas of a pathological brain network;
- said brain modulation device having at least one stimulation subsystem and at least one sensing subsystem which are coupled to a control subsystem, said control subsystem configured to modulate the pathological network and thereby increase the likelihood of normalizing the network.
- View Dependent Claims (17, 18, 19)
- 20. A method of treating at least one characteristic of a brain disorder using a brain modulation system to modulate at least two regions of a brain wherein the stimulation protocol for stimulating a first region is modified due to the stimulation protocol for stimulating at least a second region.
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