Method of treating skin ulcers using oxidative reductive potential water solution

• US 20060235350A1
• Filed: 03/23/2006
• Published: 10/19/2006
• Est. Priority Date: 03/23/2005
• Status: Active Grant

• Current Assignee: Sonoma Pharmaceuticals, Inc.
• Original Assignee: Oculus Innovative Sciences, Inc
• Inventors: Gutierrez, Andres, Alimi, Hojabr
• Granted Patent: US 8,323,252 B2
• Time in Patent Office: Days
• US Class Current: 604/19
• CPC Class Codes: A61K 33/20 Elemental chlorine; Inorganic compounds releasing chlorine
• CPC Class Codes: A61L 2/0088 Liquid substances
• CPC Class Codes: A61N 1/44 Applying ionised fluids ion generators H01J37/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/02 Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

Provided is a method of treating skin ulcers and related complications in patients by administering an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours.

Claims

1. A method of treating a skin ulcer in a patient comprising administering an oxidative reductive potential (ORP) water solution to the patient in an amount effective to treat the skin ulcer, wherein the solution has a pH of about 6.4 to about 7.8 and is stable for at least about one week.

2. The method of claim 1, wherein the solution is stable for at least about two months.

3. The method of claim 2, wherein the solution is stable for at least about one year.

4. The method of claim 1, wherein the pH is from about 7.4 to about 7.6.

5. The method of claim 1, wherein the solution comprises anode water and cathode water.

6. The method of claim 5, wherein the cathode water is present in an amount of from about 10% by volume to about 50% by volume of the solution.

7. The method of claim 5, wherein the cathode water is present in an amount of from about 20% by volume to about 40% by volume of the solution.

8. The method of claim 1, wherein the anode water is present in an amount of from about 50% by volume to about 90% by volume of the solution.

9. The method of claim 1, wherein the solution comprises at least one free chlorine species.

10. The method of claim 9, wherein the free chlorine species comprises hypochlorous acid, hypochlorite ions or a combination thereof.

11. The method of claim 9, wherein the amount of free chlorine species is from about 10 ppm to about 400 ppm.

12. The method of claim 9, wherein the free chlorine species is hypochlorous acid present in an amount of from about 15 ppm to about 35 ppm.

13. The method of claim 12, wherein the free chlorine species is sodium hypochlorite present in an amount from about 25 ppm and to 50 ppm.

14. The method of claim 1, wherein the solution comprises hypochlorous acid in an amount of from about 15 ppm to about 35 ppm and sodium hypochlorite in an amount of from about 25 ppm to about 50 ppm.

15. The method of claim 1, wherein the solution is administered to the patient by washing or irrigating the skin ulcer with the solution.

16. The method of claim 1, wherein the solution is administered to the patient by soaking the skin ulcer in the solution.

17. The method of claim 16, wherein the skin ulcer is soaked in the solution for at least about one minute.

18. The method of claim 16, wherein the skin ulcer is soaked in the solution for at least about two minutes.

19. The method of claim 1, wherein the solution is administered to the patient by dressing the skin ulcer with a wound dressing saturated with the solution.

20. The method of claim 19, wherein the wound dressing is changed daily.

22. The method of claim 1, further comprising debriding the skin ulcer.

27. The method of claim 1, wherein the skin ulcer is located on the upper extremity.

28. The method of claim 27, wherein the skin ulcer is located on the hand or fingers.

29. The method of claim 1, wherein the skin ulcer is located on the lower extremity.

30. The method of claim 29, wherein the skin ulcer is located on the foot.

31. The method of claim 1, wherein the skin ulcer is caused by arterial insufficiency, venous insufficiency, lymphatic insufficiency, pressure, neuropathy, trauma or a combination thereof.

32. The method of claim 1, wherein the skin ulcer is caused by a metabolic, inflammatory, infectious, neoplastic, degenerative or hereditary disease or a combination thereof.

33. The method of claim 1, wherein the skin ulcer is caused by diabetes.

34. The method of claim 1, wherein the skin ulcer is caused by atherosclerosis.

35. The method of claim 31, wherein the pressure results from immobility, paralysis or obesity of the patient.

36. A method of reducing the microbial load of a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

37. A method of decreasing the recurrence rate of a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

38. A method of decreasing the likelihood of dehiscence of a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

39. A method of decreasing the likelihood of amputation resulting from a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

40. A method of decreasing the likelihood of systemic inflammatory response syndrome resulting from a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

41. A method of decreasing the likelihood of sepsis resulting from a skin ulcer in a patient comprising treating the skin ulcer in accordance with the method of claim 1.

21. A method of treating a skin ulcer in a patient:

(1) washing or irrigating the ulcer with an oxidative reductive potential (ORP) water solution;

(2) soaking the ulcer in the ORP water solution;

(3) dressing the ulcer with a wound dressing saturated with the ORP water solution, and, (4) optionally repeating steps (1)-(3), wherein the solution has a pH of about 6.4 to about 7.8 and is stable for at least about one week.

23. A method of treating a skin ulcer in a patient:

(1) debriding the ulcer;

(2) washing or irrigating the ulcer with an ORP water solution;

(3) soaking the ulcer in the solution for at least two minutes;

(4) drying the ulcer for at least about two minutes;

(5) dressing the ulcer with a wound dressing saturated with the solution; and

(6) optionally repeating steps (1)-(5), wherein the skin ulcer is an infected Grade 2 or Grade 3 foot ulcer, said ulcer having a surface area of at least about 2.0 cm², wherein the solution has a pH of about 6.4 to about 7.8 and is stable for at least about one week.

24. The method of claim 23, wherein the skin ulcer is a foot ulcer in a diabetic patient.

25. The method of claim 23, further comprising repeating steps (1)-(5) at least one time.

26. The method of claim 23, further comprising repeating steps (1)-(5) until the ulcer is substantially healed.