Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation

• US 20060263405A1
• Filed: 10/04/2004
• Published: 11/23/2006
• Est. Priority Date: 10/02/2003
• Status: Active Grant

• Current Assignee: Tikomed AB
• Original Assignee: Tikomed AB
• Inventors: Nilsson, Bo, Bruce, Lars, Korsgren, Olle, Bruce, Adam
• Granted Patent: US 7,955,613 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

A bioartificial implant comprises a semipermeable barrier designed from one side to allow diffusion or prevent diffusion of predetermined substances/materials/molecules/cells/cell lines produced in the human body to the other opposite side of the barrier, and from said other opposite side to allow diffusion or prevent diffusion of predetermined substances which are the same as or different from the first mentioned substances/materials/molecules/cells/cell lines. The semipermeable barrier has a surface coating at least on said one side a bioactive metal, such as titanium, which surface coating is permeable to allow said diffusions. In a method for reducing the risk of formation/growth of connective tissue in connection with an implant which comprises a semipermeable barrier, the barrier is provided at least on one side with a permeable coating of bioactive metal. An example of the use of the implant is bioartificial pancreas.

Claims

1. A bioartificial implant, comprising,

a semipermeable barrier designed

from one sides to allow diffusion or prevent diffusion of at least one of substances, materials, molecules, cells, and cell lines produced in the human body to an opposite side of the barrier, and designed

from said opposite side to allow diffusion or prevent diffusion of substances which are the same as or different from the substances, materials, molecules, cells, and cell lines,

the semipermeable barrier including a surface coating of a bioactive metal, said surface coating being permeable to allow or prevent said diffusions.

3. The bioartificial implant as claimed in claim 1, wherein the metal is applied by an atomising process.

4. The bioartificial implant as claimed in claim 1, wherein the bio-artificial implant is in the form of a container.

5. The bioartificial implant as claimed in claim 1, wherein the barrier has the surface coating on both sides.

6. The bioartificial implant as claimed in claim 1, wherein at least one of the coatings has a thickness from about 5 nm, such as about 50-250 nm.

7. A method, comprising:

using the bioartificial implant, as claimed in claim 1, as a bioartificial pancreas.

8. A method, comprising:

using the bioartificial implant, as claimed in claim 1, as part of a sensor on a measuring instrument.

11. The bioartificial implant of claim 1, wherein the surface coating of a bioactive metal includes titanium.

19. The bioartificial implant as claimed in claim 1, wherein at least one of the coatings has a thickness of about 50-250 nm.

2. A bioartificial implants comprising:

a semipermeable barrier designed

from one side, to allow diffusion of body cell nutrient and oxygen from a body of a donee to an opposite side of the barrier where at least one of body organ and cells from a donor are positioned, and designed

from said opposite side to allow diffusion of substances selected in advance, produced by at least one of the body organ and cells from the donor,

the semipermeable barrier including a surface coating on said one side of

a bioactive metal, said surface coating being permeable to allow said diffusions.

12. The bioartificial implant of claim 2, wherein the surface coating of a bioactive metal includes titanium.

13. The bioartificial implant as claimed in claim 2, wherein the metal is applied by an atomising process.

14. The bioartificial implant as claimed in claim 2, wherein the bioartificial implant is in the form of a container.

15. The bioartificial implant as claimed in claim 2, wherein the barrier has the surface coating on both sides.

16. The bioartificial implant as claimed in claim 2, wherein at least one of the coatings has a thickness from about 5 nm, such as about 50-250 nm.

17. A method, comprising:

using the bioartificial implant, as claimed in claim 2, as a bioartificial pancreas.

18. A method, comprising:

using the bioartificial implant, as claimed in claim 2, as part of a sensor on a measuring instrument.

20. The bioartificial implant as claimed in claim 2, wherein at least one of the coatings has a thickness of about 50-250 nm.

9. A method for reducing the risk of at least one of formation and growth of connective tissue in connection with an implant including a semipermeable barrier, the method comprising:

providing the barrier, at least on one side, with a permeable coating of bioactive metal.

10. The method as claimed in claim 9, wherein the coating is prepared by atomising.