Systems and methods for monitoring pharmacological parameters
First Claim
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1. A system for monitoring more than one pharmacological parameter useful for assessing efficacy and/or toxicity of a therapeutic agent, comprising:
- a) a fluidic device comprising a cartridge, said cartridge comprising at least one sample collection unit and an assembly;
wherein said sample collection unit allows a sample of bodily fluid comprising a plurality of analytes indicative or said more than one pharamcological parameter to react with reactants contained within said assay assembly, said reaction yields detectable signals indicative of the values of the more than one pharmacological parameter from said sample of bodily fluid;
b) a reader assembly comprising a detection assembly for detecting said detectable signals; and
c) a communication assembly for transmitting said detected signals to an external device.
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Abstract
This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
204 Citations
29 Claims
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1. A system for monitoring more than one pharmacological parameter useful for assessing efficacy and/or toxicity of a therapeutic agent, comprising:
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a) a fluidic device comprising a cartridge, said cartridge comprising at least one sample collection unit and an assembly;
wherein said sample collection unit allows a sample of bodily fluid comprising a plurality of analytes indicative or said more than one pharamcological parameter to react with reactants contained within said assay assembly, said reaction yields detectable signals indicative of the values of the more than one pharmacological parameter from said sample of bodily fluid;
b) a reader assembly comprising a detection assembly for detecting said detectable signals; and
c) a communication assembly for transmitting said detected signals to an external device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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9. The system of 8, wherein the immunoassay reagents detect a polypeptide glycoprotein, polysaccharide, lipid, nucleic acid, and a combination thereof.
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21. A method of monitoring more than one pharmacological parameter useful for assessing efficacy and/or toxicity of a therapeutic agent, comprising:
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a) subjecting a sample of bodily fluid from a subject administered with the pharmaceutical agent to a fluidic device for profiling said more than one pharmacological parameter, said fluidic medical device comprising a cartridge, said cartridge comprising at least one sample collection unit, and an assay assembly comprising reaction reagents;
b) actuating said fluidic device and directing said immunoassay reagents within said fluidic device;
c) allowing said sample of bodily fluid to react with immunoassay reagents to yield detectable signals indicative of the values of the more than one pharmacological parameter from said sample;
d) detecting said detectable signal generated from said sample of bodily fluid. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification