Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26
First Claim
1. A method of identifying a human subject having an increased risk of developing Age-Related Maculopathy comprising identifying in a nucleic acid sample from the subject the occurrence of an allelic variant located in Chromosome 10q26 that is associated with risk of developing Age-Related Maculopathy.
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Accused Products
Abstract
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an array, are identified as being useful in implementing those methods.
28 Citations
33 Claims
- 1. A method of identifying a human subject having an increased risk of developing Age-Related Maculopathy comprising identifying in a nucleic acid sample from the subject the occurrence of an allelic variant located in Chromosome 10q26 that is associated with risk of developing Age-Related Maculopathy.
- 26. An array comprising a substrate comprising in an identifiable locus one or more reagents for identifying in a nucleic acid sample from a subject the occurrence of an allelic variation located on Chromosome 10q26 that is associated with risk of development of Age-Related Maculopathy.
Specification