Valve for facilitating and maintaining fluid separation

• US 20070003449A1
• Filed: 06/12/2006
• Published: 01/04/2007
• Est. Priority Date: 06/10/2005
• Status: Abandoned Application

• Current Assignee: Matin Ebneshahrashoob, Mehdi Hatamian, Mehrtosh Ghalebi
• Original Assignee: Matin Ebneshahrashoob, Mehdi Hatamian, Mehrtosh Ghalebi
• Inventors: Hatamian, Mehdi, Ghalebi, Mehrtosh, Ebneshahrashoob, Matin
• Application Number:
  US11/451,240
• Publication Number:
  US 20070003449A1
• Time in Patent Office: Days
• US Class Current: 422/103
• CPC Class Codes: B01L 2300/042 Caps; Plugs
• CPC Class Codes: B01L 2400/0616 Ball valves
• CPC Class Codes: B01L 2400/0633 with moving parts
• CPC Class Codes: B01L 3/5021 Test tubes specially adapted for centrifugation purposes centrifuges B04B5/04

Abstract

Some embodiments include a valve positioned within a test tube to maintain a separation between components of liquid with different densities after centrifugation. The valve preferably includes a cylindrically shaped housing with a spherical plug configured to nest within the housing. The valve permits varying amounts of fluid flow depending upon the angular velocity of centrifugation applied to the test tube.

Claims

1. A medical valve for insertion into a container, the valve comprising:

a first component sized to fit into a generally cylindrical bore of a container and configured to contact an inner surface of the container, the first component having a central opening, a floor, and a substantially circular entrance port flap that is thinner than the floor;

a second component sized to fit inside the central opening, the second component configured to move with respect to the first component when the valve is inside a container during centrifugation such that a fluid passageway between the two components is open during centrifugation but closed after centrifugation when the second component generally fills the central opening and seats against the narrow portion of the second component.

2. The valve of claim 1, wherein at least one of the first and second components is resilient.

3. The valve of claim 1, wherein at least one of the first and second components made of silicone.

4. The valve of claim 1, wherein the first component further comprises a plurality of tapering spacers in a sloping portion.

5. The valve of claim 1, wherein the resilient portion is formed integrally with the first portion.

6. The valve of claim 5, wherein the resilient portion is a floor.

7. The valve of claim 1, wherein the first component comprises a cavity with a structure between the entrance port flap and the floor that assists in centering the second component in the cavity.

8. The valve of claim 7, wherein the structure is a plurality of radially inwardly facing ridges.

9. The valve of claim 1, wherein the second component comprises a plug.

10. The valve of claim 7, wherein the plug is non-metal and is more dense than the material of the housing.

11. The valve of claim 7, wherein the plug comprises a material selected from the group consisting of a polyolephine, an acrylic, a ceramic, and a glass.

12. The valve of claim 1, wherein the second component comprises a generally spherical ball.

13. The valve of claim 1, wherein the first component has first and second upper surfaces, the second surface having a steeper slope than the first surface, and the first surface being adjacent to the second surface and the first surface being farther from the floor than the second surface.

14. The valve of claim 4, wherein the spacers do not extend to the furthest edge of the sloping portion opposite from the floor.

15. The valve of claim 12, wherein the dimensions of the ball and a cavity within the first portion permit a portion of the ball to be positioned within the cavity and a portion of the ball to be positioned outside of the cavity after centrifugation.

16. A medical valve comprising:

a first portion comprising a plug, a resilient tether, and a suspension portion, the resilient tether connecting the plug and the suspension portion; and

a second portion comprising a valve housing having a central passage that generally encircles the tether such that the plug and suspension portions are generally located on either side of the second portion.

17. The medical valve of claim 16 wherein the first portion is a unitary portion.

18. The medical valve of claim 17, wherein the first portion is silicone.

19. The medical valve of claim 16, wherein the second portion is a unitary portion formed from silicone.

20. The medical valve of claim 16, wherein the plug is generally ball-shaped.

21. The medical valve of claim 16, wherein the plug is generally tear-drop shaped.

22. The medical valve of claim 16, wherein the tether is configured to stretch and open a passageway between the first and second portions when subject to centrifugation.

23. The medical valve of claim 16, wherein the second portion is configured to slide down the inside of a sample container when the sample container is rotated in a centrifuge.

24. The medical valve of claim 16, wherein the suspension portion is configured to remain stationary in a sample container when the sample container is rotated in a centrifuge.

25. The medical valve of claim 16, wherein the tether is offset from the axis of cylindrical symmetry of a test tube when the first portion is placed within the test tube.

26. The medical valve of claim 16, wherein the valve housing further comprises a protruding lip that extends toward the plug that is configured to seat against the plug when the tether pulls the plug toward the valve housing.

27. A medical valve system comprising:

a sample container;

a suspension portion;

a plug;

a valve housing; and

a resilient tether that passes through the valve housing and connects the suspension portion to the plug.

28. The medical valve system of claim 27, wherein the sample container comprises a test tube.

29. The medical valve of system of claim 27, wherein the plug comprises a silicone ball.

30. The medical valve system of claim 27, wherein the suspension portion, the plug, and the resilient tether are a unitary portion.

31. The medical valve system of claim 27, wherein the suspension portion comprises a central passage configured to allow fluid to flow into a sample container.

32. The medical valve system of claim 27, further comprising an upper chamber inside the sample container above the valve housing and a lower chamber inside the sample container below the valve housing, wherein the valve housing comprises a central passage configured to allow fluid to flow between the upper and lower chambers.

33. The medical valve system of claim 32, the plug further comprising a generally conical portion and the valve housing further comprising a narrow ring portion that extends toward the central axis of the sample container, the generally conical portion configured to seat against the narrow ring portion to block fluid flow between the upper chamber and the lower chamber.