Antimicrobial silver compositions

• US 20070003603A1
• Filed: 08/01/2005
• Published: 01/04/2007
• Est. Priority Date: 07/30/2004
• Status: Active Grant

• Current Assignee: Avent Incorporated (Avanos Medical, Inc.)
• Original Assignee: Avent Incorporated (Avanos Medical, Inc.)
• Inventors: Cornell, Ken, Karandikar, Bhalchandra, Gibbins, Bruce
• Granted Patent: US 8,900,624 B2
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/22 containing ingredients stabilising the active ingredients
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/06 Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 43/50 1,3-Diazoles; Hydrogenated 1,3-diazoles
• CPC Class Codes: A01N 43/80 five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/624 Nanocapsules
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/106 : Inorganic materials other than carbon
• CPC Class Codes: A61L 29/16 : Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: C08J 2323/12 : Polypropene
• CPC Class Codes: C08J 2327/06 : Homopolymers or copolymers of vinyl chloride
• CPC Class Codes: C08J 2327/18 : Homopolymers or copolymers of tetrafluoroethylene
• CPC Class Codes: C08J 2375/04 : Polyurethanes
• CPC Class Codes: C08J 2377/02 : Polyamides derived from omega-amino carboxylic acids or from lactams thereof C08J2377/10 takes precedence
• CPC Class Codes: C23C 18/1637 : metallic substrate
• CPC Class Codes: C23C 18/1639 : Substrates other than metallic, e.g. inorganic or organic or non-conductive
• CPC Class Codes: C23C 18/1641 : Organic substrates, e.g. resin, plastic
• CPC Class Codes: C23C 18/1646 : Characteristics of the product obtained
• CPC Class Codes: C23C 18/1689 : After-treatment
• CPC Class Codes: C23C 18/44 : using reducing agents
• CPC Class Codes: D06M 11/83 : with metals; with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
• CPC Class Codes: D06M 16/00 : Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
• CPC Class Codes: D06M 23/08 : Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00
• CPC Class Codes: Y10S 977/906 : Drug delivery

Abstract

The present invention comprises methods and compositions for antimicrobial silver compositions comprising silver nanoparticles. The present invention further comprises compositions for preparing silver nanoparticles comprising at least one stabilizing agent, one or more silver compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the silver compound comprises a salt comprising a silver cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates. The methods of the present invention comprise treating devices with the silver nanoparticle compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals wacr6ith the antimicrobial devices described herein.

Claims

1. A composition comprising, a solvent, silver nanoparticles, and a stabilizing agent.

2. The composition of claim 1, wherein the solvent is aqueous or non-aqueous.

3. The composition of claim 2, wherein the aqueous solvent is water.

4. The composition of claim 2, wherein the solvent is methylene chloride, chloroform other aliphatic and aromatic chlorinated solvents, cyclohexane, diethyl ether, ethyl acetate and mixtures thereof.

5. The composition of claim 1, wherein the stabilizing agent is a polymer, a surfactant or both.

6. The composition of claim 5, wherein the polymer is a homopolymer copolymer, synthetic or naturally derived, acrylamide and its derivatives, methacrylamide and its derivatives, polyamides, polyurethanes, polymers having no particular backbone but with urethane segments or tertiary amine groups in the side chains, other polymers predominantly polar in nature or co-polymers having a portion that is derived from polar co-monomers, methaacrylamide, substituted acrylamides, substituted methaacrylamides, acrylic acid, methacrylic acid, hydroxyethyl methacrylate, acrylonitrile, 2-acrylamido-2-methylpropane sulfonic acid and its salts (sodium, potassium, ammonium), 2-vinyl pyrrolidone, 2-vinyl oxazoline, vinyl acetate, maleic anhydride.

7. The composition of claim 5, wherein the surfactant is an anionic, nonionic, or amphoteric surfactant.

8. A method of making silver nanoparticles comprising,

a) adding in no particular order, an aqueous solution of a stabilizing agent solution, an anionic donating solution and a soluble silver salt solution, and

b) adding a tertiary diamine solution.

9. The method of claim 8, further comprising, c) heating the final solution to increase the reaction.

10. The method of claim 8, wherein the stabilizing agent solution comprises a surfactant, a polymer or both.

11. The method of claim 10, wherein the polymer polymer is a homopolymer copolymer, synthetic or naturally derived, polymers of acrylamide and its derivatives, methacrylamide and its derivatives, polyamides, polyurethanes, polymers having no particular backbone but with urethane segments or tertiary amine groups in the side chains, other polymers predominantly polar in nature or co-polymers having a portion that is derived from polar co-monomers, methaacrylamide, substituted acrylamides, substituted methaacrylamides, acrylic acid, methacrylic acid, hydroxyethyl methacrylate, acrylonitrile, 2-acrylamido-2-methylpropane sulfonic acid and its salts (sodium, potassium, ammonium), 2-vinyl pyrrolidone, 2-vinyl oxazoline, vinyl acetate, maleic anhydride.

12. The method of claim 8, further comprising, forming the nanoparticles in situ on the surface of an article.

13. The method of claim 12, wherein the article is a woven or nonwoven fiber article article.

14. The method of claim 12, wherein the article is a medical device, polymer, a fiber, a metal, glass, ceramic, fabric or combination thereof.

15. The method of claim 8, further comprising, extracting the nanoparticles into a non-aqueous solution.

16. A method of treating a surface with silver nanoparticles, comprising,

a) contacting a surface with a solution comprising silver nanoparticles for a time sufficient for an effective amount of nanoparticles to bind to the surface, and

b) rinsing the solution from the surface.

17. The method of claim 16, wherein the contacting and rinsing steps are repeated multiple times to increase the number of nanoparticles adhering to the surface.

18. The method of claim 16, wherein the surface contacted is a medical device, polymer, a fiber, a metal, glass, ceramic, fabric or combination thereof.

19. The method of claim 16, further comprising

c) contacting the surface with nanoparticles adhered thereto with an aqueous solution of hydrogen peroxide for a sufficient period of time, and

d) rinsing the hydrogen peroxide solution from the surface.

20. The method of claim 19, wherein the surface contacted is a medical device, polymer, a fiber, a metal, glass, ceramic, fabric or combination thereof.