Amino acid and metabolite biosynthesis

  • US 20070026505A1
  • Filed: 06/19/2006
  • Published: 02/01/2007
  • Est. Priority Date: 06/17/2005
  • Status: Abandoned Application
First Claim
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1. An Enterobacteriaceae or coryneform bacterium comprising at least one isolated nucleic acid molecule selected from the group consisting of:

  • (a) a nucleic acid molecule comprising a sequence encoding a bacterial sulfate ABC transporter ATP-binding polypeptide or a functional variant thereof;

    (b) a nucleic acid molecule comprising a sequence encoding a bacterial sulfate transport system permease W polypeptide or a functional variant thereof;

    (c) a nucleic acid molecule comprising a sequence encoding a bacterial sulfate, thiosulfate transport system permease T polypeptide or a functional variant thereof;

    (d) a nucleic acid molecule comprising a sequence encoding a bacterial sulfate adenylyltransferase subunit 1 polypeptide or a functional variant thereof;

    (e) a nucleic acid molecule comprising a sequence encoding a bacterial sulfate adenylyltransferase subunit 2 polypeptide or a functional variant thereof;

    (f) a nucleic acid molecule comprising a sequence encoding a bacterial adenylylsulfate kinase polypeptide or a functional variant thereof;

    (g) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoadenosine phosphosulfate reductase polypeptide or a functional variant thereof;

    (h) a nucleic acid molecule comprising a sequence encoding a bacterial sulfite reductase alpha subunit polypeptide or a functional variant thereof;

    (i) a nucleic acid molecule comprising a sequence encoding a bacterial sulfite reductase hemopolypeptide beta-component polypeptide or a functional variant thereof;

    (j) a nucleic acid molecule comprising a sequence encoding a bacterial sulfite reductase (NADPH), flavopolypeptide beta subunit polypeptide or a functional variant thereof;

    (k) a nucleic acid molecule comprising a sequence encoding a bacterial adenylyl-sulphate reductase alpha subunit polypeptide or a functional variant thereof;

    (l) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoglycerate dehydrogenase polypeptide or a functional variant thereof;

    (m) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoserine transaminase polypeptide or a functional variant thereof;

    (n) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoserine phosphatase polypeptide or a functional variant thereof;

    (o) a nucleic acid molecule comprising a sequence encoding a bacterial serine O-acetyltransferase polypeptide or a functional variant thereof;

    (p) a nucleic acid molecule comprising a sequence encoding a bacterial cysteine synthase A polypeptide or a functional variant thereof;

    (q) a nucleic acid molecule comprising a sequence encoding a bacterial cysteine synthase B polypeptide or a functional variant thereof;

    (r) a nucleic acid molecule comprising a sequence encoding a bacterial ABC-type vitamin B12 transporter permease component polypeptide or a functional variant thereof;

    (s) a nucleic acid molecule comprising a sequence encoding a bacterial ABC-type vitamin B12 transporter ATPase component polypeptide or a functional variant thereof;

    (t) a nucleic acid molecule comprising a sequence encoding a bacterial ABC-type cobalamin/Fe3+-siderophore transport system polypeptide or a functional variant thereof;

    (u) a nucleic acid molecule comprising a sequence encoding a bacterial adenosyltransferase polypeptide or a functional variant thereof;

    (v) a nucleic acid molecule comprising a sequence encoding a bacterial GTP cyclohydrolase I polypeptide or a functional variant thereof;

    (w) a nucleic acid molecule comprising a sequence encoding a bacterial phoA, psiA, or psiF gene product polypeptide or a functional variant thereof;

    (x) a nucleic acid molecule comprising a sequence encoding a bacterial dihydroneopterin aldolase polypeptide or a functional variant thereof;

    (y) a nucleic acid molecule comprising a sequence encoding a bacterial 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase polypeptide or a functional variant thereof;

    (z) a nucleic acid molecule comprising a sequence encoding a bacterial dihydropteroate synthase polypeptide or a functional variant thereof;

    (aa) a nucleic acid molecule comprising a sequence encoding a bacterial dihydrofolate synthetase polypeptide or a functional variant thereof;

    (ab) a nucleic acid molecule comprising a sequence encoding a bacterial dihydrofolate reductase polypeptide or a functional variant thereof;

    (ac) a nucleic acid molecule comprising a sequence encoding a bacterial folylpolyglutamate synthetase polypeptide or a functional variant thereof;

    (ad) a nucleic acid molecule comprising a sequence encoding a putative bacterial methionine (APC transporter superfamily) permease (YjeH) polypeptide or a functional variant thereof;

    (ae) a nucleic acid molecule comprising a sequence encoding a bacterial transcriptional activator of MetE/H polypeptide or a functional variant thereof;

    (af) a nucleic acid molecule comprising a sequence encoding a bacterial 6-phosphogluconate dehydrogenase polypeptide or a functional variant thereof;

    (ag) a nucleic acid molecule comprising a sequence encoding a bacterial S-methylmethionine homocysteine methyltransferase polypeptide or a functional variant thereof;

    (ah) a nucleic acid molecule comprising a sequence encoding a bacterial S-adenosylhomocysteine hydrolase polypeptide or a functional variant thereof;

    (ai) a nucleic acid molecule comprising a sequence encoding a bacterial site-specific DNA methylase polypeptide or a functional variant thereof;

    (aj) a nucleic acid molecule comprising a sequence encoding a bacterial methionine export sytem protein 1 polypeptide or a functional variant thereof;

    (ak) a nucleic acid molecule comprising a sequence encoding a bacterial methionine export sytem protein 2 polypeptide or a functional variant thereof;

    (al) a nucleic acid molecule comprising a sequence encoding a bacterial ABC transport system ATP-binding protein (MetN) polypeptide or a functional variant thereof;

    (am) a nucleic acid molecule comprising a sequence encoding a bacterial ABC transport system permease protein (MetP) polypeptide or a functional variant thereof;

    (an) a nucleic acid molecule comprising a sequence encoding a bacterial ABC transport system substrate-binding protein (MetQ) polypeptide or a functional variant thereof;

    (ao) a nucleic acid molecule comprising a sequence encoding a bacterial aspartokinase polypeptide or a functional variant thereof;

    (ap) a nucleic acid molecule comprising a sequence encoding a bacterial aspartate semialdehyde dehydrogenase or a functional variant thereof;

    (aq) a nucleic acid molecule comprising a sequence encoding a bacterial homoserine dehydrogenase polypeptide or a functional variant thereof;

    (ar) a nucleic acid molecule comprising a sequence encoding a bacterial O-homoserine acetyl transferase polypeptide or a functional variant thereof;

    (as) a nucleic acid molecule comprising a sequence encoding a bacterial O-acetylhomoserine sulfhydrylase polypeptide or a functional variant thereof;

    (at) a nucleic acid molecule comprising a sequence encoding a bacterial cobalamin-dependent methionine synthase polypeptide or a functional variant thereof;

    (au) a nucleic acid molecule comprising a sequence encoding a bacterial cobalamin-independent methionine synthase polypeptide or a functional variant thereof;

    (av) a nucleic acid molecule comprising a sequence encoding a bacterial homoserine kinase polypeptide or a functional variant thereof;

    (aw) a nucleic acid molecule comprising a sequence encoding a bacterial methionine adenosyltransferase polypeptide or a functional variant thereof;

    (ax) a nucleic acid molecule comprising a sequence encoding a bacterial O-succinylhomoserine (thio)-lyase polypeptide or a functional variant thereof;

    (ay) a nucleic acid molecule comprising a sequence encoding a bacterial cystathionine beta-lyase polypeptide or a functional variant thereof;

    (az) a nucleic acid molecule comprising a sequence encoding a bacterial 5,10-methylenetetrahydrofolate reductase polypeptide or a functional variant thereof;

    (ba) a nucleic acid molecule comprising a sequence encoding a bacterial dihydrodipicolinate synthase polypeptide or a functional variant thereof;

    (bb) a nucleic acid molecule comprising a sequence encoding a bacterial pyruvate carboxylase polypeptide or a functional variant thereof;

    (bc) a nucleic acid molecule comprising a sequence encoding a bacterial glutamate dehydrogenase polypeptide or a functional variant thereof;

    (bd) a nucleic acid molecule comprising a sequence encoding a bacterial diaminopimelate dehydrogenase polypeptide or a functional variant thereof;

    (be) a nucleic acid molecule comprising a sequence encoding a bacterial methionine and cysteine biosynthesis repressor (McbR) polypeptide or a functional variant thereof;

    (bf) a nucleic acid molecule comprising a sequence encoding a bacterial lysine exporter protein polypeptide or a functional variant thereof;

    (bg) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoenolpyruvate carboxykinase polypeptide or a functional variant thereof;

    (bh) a nucleic acid molecule comprising a sequence encoding a bacterial phosphoenolpyruvate carboxylase polypeptide or a functional variant thereof;

    (bi) a nucleic acid molecule comprising a sequence encoding a bacterial glycine dehydrogenase (decarboxylating) polypeptide or a functional variant thereof;

    (bj) a nucleic acid molecule comprising a sequence encoding a bacterial H polypeptide (involved in the glycine cleavage system) or a functional variant thereof;

    (bk) a nucleic acid molecule comprising a sequence encoding a bacterial aminomethyl transferase polypeptide or a functional variant thereof;

    (bl) a nucleic acid molecule comprising a sequence encoding a bacterial dihydrolipoamide dehydrogenase polypeptide or a functional variant thereof;

    (bm) a nucleic acid molecule comprising a sequence encoding a bacterial lipoate-protein ligase A polypeptide or a functional variant thereof;

    (bn) a nucleic acid molecule comprising a sequence encoding a bacterial lipoic acid synthase polypeptide or a functional variant thereof;

    (bo) a nucleic acid molecule comprising a sequence encoding a bacterial lipoyl-[acyl-carrier-protein]-protein-N-lipoyltransferase polypeptide or a functional variant thereof;

    (bp) a nucleic acid molecule comprising a sequence encoding a bacterial fructose 1,6 bisphosphatase polypeptide or a functional variant thereof;

    (bq) a nucleic acid molecule comprising a sequence encoding a bacterial glucose 6 phosphate dehydrogenase polypeptide or a functional variant thereof;

    (br) a nucleic acid molecule comprising a sequence encoding a glucose-6-phosphate isomerase polypeptide or a functional variant thereof; and

    (bs) a nucleic acid molecule comprising a sequence encoding a bacterial NCgl2640 polypeptide or a functional variant thereof

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