Nucleic acid and amino acid sequences relating to Candida albicans for diagnostics and therapeutics
First Claim
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1. An isolated nucleic acid comprising a nucleotide sequence encoding an C. albicans polypeptide selected from the group consisting of SEQ ID NO:
- 14104-SEQ ID NO;
28206.
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Abstract
The invention provides isolated polypeptide and nucleic acid sequences derived from Candida albicans that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from fungal infection.
33 Citations
28 Claims
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1. An isolated nucleic acid comprising a nucleotide sequence encoding an C. albicans polypeptide selected from the group consisting of SEQ ID NO:
- 14104-SEQ ID NO;
28206. - View Dependent Claims (2, 3, 4)
- 14104-SEQ ID NO;
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5. An isolated nucleic acid comprising a nucleotide sequence encoding an C. albicans polypeptide or a fragment thereof, said nucleic acid selected from the group consisting of SEQ ID NO:
- 1-SEQ ID NO;
14103. - View Dependent Claims (6, 7, 8, 11, 12, 13, 14, 15, 16, 24)
- 1-SEQ ID NO;
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9. A probe comprising a nucleotide sequence having at least 8 consecutive nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1-SEQ ID NO;
14103.
- 1-SEQ ID NO;
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10. An isolated nucleic acid comprising a nucleotide sequence of at least 8 nucleotides in length, wherein the sequence is hybridizable to a nucleic acid having a nucleotide sequence selected from the group consisting of SEQ ID NO:
- 1-SEQ ID NO;
14103.
- 1-SEQ ID NO;
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17. A recombinant or substantially pure preparation of an C. albicans polypeptide or a fragment thereof, wherein said polypeptide is selected from the group consisting of SEQ ID NO:
- 14104-SEQ ID NO;
28206. - View Dependent Claims (18, 19, 20, 21, 22, 23)
- 14104-SEQ ID NO;
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25. A computer readable medium having recorded thereon the nucleotide sequences depicted in SEQ ID NO:
- 1-SEQ ID NO;
14103 or fragments thereof.
- 1-SEQ ID NO;
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26. A computer based system for identifying fragments of the Candida genome of commercial importance comprising the following elements;
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a) a data storage means comprising the nucleotide sequences SEQ ID NO;
1-SEQ ID NO;
14103 or fragments thereof,b) a search means for comparing a target sequence to the nucleotide sequences of the data storage means of step (a) to identify homologous sequences, and;
c) a retrieval means for obtaining said homologous sequences(s) of step (b).
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27. A method of identifying commercially important nucleic acid fragments of the Candida genome comprising the step of comparing a database comprising the nucleotide sequences SEQ ID NO:
- 1-SEQ ID NO;
14103 or fragments thereof with a target sequence to obtain a nucleic acid molecule comprised of a complementary nucleotide sequence to said target sequence, wherein said target sequence is not randomly selected.
- 1-SEQ ID NO;
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28. A method for identifying an expression modulating fragment of the Candida genome comprising the step of comparing a database comprising the nucleotide sequences SEQ ID NO:
- 1-SEQ ID NO;
14103 or fragments thereof with a target sequence to obtain a nucleic acid molecule comprised of a complementary nucleotide sequence to said target sequence, wherein said target sequence comprises sequences known to regulate gene expression.
- 1-SEQ ID NO;
Specification