Repair of tympanic membrane using placenta derived collagen biofabric

• US 20070038298A1
• Filed: 06/29/2006
• Published: 02/15/2007
• Est. Priority Date: 06/30/2005
• Status: Abandoned Application

• Current Assignee: Anthrogenesis Corporation (Bristol-Myers Squibb Company)
• Original Assignee: Anthrogenesis Corporation (Bristol-Myers Squibb Company)
• Inventors: Smiell, Janice, Sulner, Joseph, Bourke, Sharon, Murphy, Patricia
• Application Number:
  US11/479,801
• Publication Number:
  US 20070038298A1
• Time in Patent Office: Days
• US Class Current: 623/10
• CPC Class Codes: A61F 2/18 Internal ear or nose parts, e.g. ear-drums implants for middle ear ventilation or drainage A61F11/202
• CPC Class Codes: A61F 2002/183 Ear parts
• CPC Class Codes: A61L 2430/14 for ear reconstruction or ear implants, e.g. implantable hearing aids
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 31/044 Collagen

Abstract

The present invention provides a method of repairing a tympanic membrane deformity, such as a tympanic membrane perforation, commonly referred to as tympanoplasty or myringoplasty, using a collagen biofabric. The collagen biofabric is preferably laminated. The invention further provides kits comprising one or more pieces of collagen biofabric, for example laminated collagen biofabric, for the repair of a tympanic membrane.

Claims

1. A method of repairing a tympanic membrane having a deformity, comprising contacting said tympanic membrane with a collagen biofabric.

2. The method of claim 1, wherein said deformity is a perforation.

3. The method of claim 1, wherein said deformity is an atelectatic tympanic membrane, a deformity relating to a choleastoma, a retraction pocket or a deformity resulting from a tympanosclerosis.

4. The method of claim 2, wherein said perforation is caused by trauma.

5. The method of claim 2, wherein said perforation is caused as part of a surgical procedure.

6. The method of claim 2, wherein said contacting is sufficient to occlude the perforation.

7. The method of claim 2, wherein said perforation has not healed spontaneously within two months of developing the perforation.

8. The method of claim 1, wherein the collagen biofabric is a single layer of amniotic membrane.

9. The method of claim 1, wherein the collagen biofabric is a laminate of two or more layers of amniotic membrane.

10. The method of claim 11, wherein said laminate has two layers and is about 20 to about 60 microns in thickness.

11. The method of claim 12 wherein said laminate is about 50 microns in thickness.

12. The method of claim 2, wherein the collagen biofabric comprises less than about 20% water by weight when contacted with the tympanic membrane.

13. The method of claim 2, wherein the collagen biofabric is hydrated prior to contacting with the tympanic membrane.

14. The method of claim 1, wherein said collagen biofabric is about 2 microns to about 150 microns in thickness.

16. The method of claim 1, wherein said collagen biofabric is provided in a double peel pouch.

17. Collagen biofabric, wherein the collagen biofabric is a laminate having two layers or more.

18. The collagen biofabric of claim 23 wherein said collagen biofabric is a laminate of two layers and which has an average thickness of about 20 to about 60 microns.

19. The collagen biofabric of claim 24 wherein said collagen biofabric has an average thickness of about 50 microns.

20. The collagen biofabric of claim 23 measuring about 3×

3 cm or less.

15. The method of claim 20, wherein said collagen biofabric is about 1 to about 40 microns in thickness.