Impulse chamber for jet delivery device

• US 20070049873A1
• Filed: 07/26/2006
• Published: 03/01/2007
• Est. Priority Date: 01/26/2004
• Status: Abandoned Application

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Hansen, Torben, Moller, Claus
• Application Number:
  US11/493,095
• Publication Number:
  US 20070049873A1
• Time in Patent Office: Days
• US Class Current: 604/187
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/482 Varying injection pressure, e.g. by varying speed of injection

Abstract

The invention relates to an impulse chamber which can be used for expelling an amount of a fluid compound at a high pressure. The impulse chamber comprises a variable-volume impulse chamber adapted for containing a volume of a flowable drug, an outlet nozzle in fluid communication with the impulse chamber and being adapted to be arranged against the skin of a subject, and a fluid inlet in fluid communication with the impulse chamber. The impulse chamber is defined substantially by a deformable chamber portion, such that deformation thereof reduces the volume of the cavity. In an exemplary embodiment the compressible chamber portion is in the form of an elastomeric tube, this providing a simple, yet reliable and cost-effective impulse chamber unit.

Claims

1. An impulse chamber unit (1, 2, 3) comprising:

a deformable chamber portion (10, 50) having an outer surface, the outer surface being substantially free,

a variable-volume impulse chamber (11, 55) defined at least partially by the deformable chamber portion and adapted for containing a volume of a flowable drug,

an outlet nozzle (23, 61) in fluid communication with the impulse chamber and being adapted to be arranged against a skin surface of a subject, and

an inlet (33, 39, 51) in fluid communication with the impulse chamber,

wherein deformation of the chamber portion (10, 50) reduces the volume of the impulse chamber.

2. An impulse chamber unit as in claim 1, wherein the chamber portion is in the form of a deformable polymeric tube comprising proximal and distal end portions.

3. An impulse chamber unit as in claim 2, wherein the outlet nozzle is formed integrally with the polymeric tube.

4. An impulse chamber unit as in claim 2, wherein the tube is formed from a substantially incompressible elastomeric material.

5. An impulse chamber unit as in claim 2, comprising a first closure member (20, 60) attached to the distal end portion, the first closure member comprising the outlet nozzle.

6. An impulse chamber unit as in claim 2, wherein the fluid inlet is provided by a proximal end opening (51) in the polymeric tube.

7. An impulse chamber unit as in claim 2, comprising a first closure member (52) attached to the distal end portion, the first closure member comprising the outlet nozzle, and a second closure member (70) attached relative to the proximal end portion, the second closure member comprising the fluid inlet.

8. An impulse chamber unit as in claim 2, wherein the variable-volume impulse chamber is defined substantially by the deformable chamber portion.

9. An impulse chamber unit as in claim 2, wherein the fluid inlet is in the form of a conduit member (33, 76) projecting from the impulse chamber unit, the conduit member optionally being in the form of a pointed hollow needle.

10. A combination of an impulse chamber unit as in any of claim 1, and a mounting device (60, 200, 420) adapted to replaceably receive the impulse chamber unit in locking engagement.

11. A combination of an impulse chamber unit as in claim 1, and a mounting device (60) adapted to replaceably receive the impulse chamber unit in locking engagement, the mounting device comprising a conduit member projecting from the mounting device and adapted to be arranged in fluid communication with the impulse chamber, the conduit member optionally being in the form of a pointed hollow needle.

12. A combination as in claim 10, wherein the mounting device comprises a mounting cavity adapted to receive the deformable chamber portion in a substantially form-fitting relationship.

13. A combination as in claim 12, wherein the deformable chamber portion has a tubular configuration with a substantially constant outer diameter along the length thereof, the mounting cavity being in the form of a bore having a diameter substantially the same as the deformable chamber portion, the bore comprising an opening (74) allowing an impulse generating element to engage a portion of the deformable chamber portion.

14. A combination as in claim 10, wherein the impulse chamber unit and the mounting device comprise releasable mating coupling means (25, 63, 79) allowing the impulse chamber unit to be secured to the mounting device in a situation of use.

15. A combination as in claim 10, the mounting device further comprising:

a coupling for arranging the fluid inlet in fluid communication with an interior of a drug reservoir, and

an impulse generator (240, 300, 422) for displacing a portion of the deformable chamber portion, thereby reducing the volume of the impulse chamber and thereby expelling an amount of a liquid drug contained in the impulse chamber through the outlet nozzle (251, 421), the impulse generator being adapted to create a pressure within the impulse chamber for injecting the liquid drug through the outlet nozzle and through a skin surface of the subject.

16. A combination (400) as in claim 15, further comprising:

a reservoir (411) comprising a liquid drug,

drive means for expelling an amount of drug from the reservoir at a reduced pressure relative to the impulse generating means,

means (412) for selectable setting a dose of drug to be expelled,

means (422) for actuating the impulse generating means and the drive means, and

actuatable release means (413), whereby actuation of the release means first causes release of the impulse generator thereby expelling an amount of drug at a high pressure from the impulse chamber through the outlet nozzle (421), followed by release of the drive means for subsequent expelling of the set dose from the reservoir via the impulse chamber through the outlet nozzle.

17. A combination (400) as in claim 15, further comprising:

a reservoir (411) comprising a liquid drug,

drive means for expelling an amount of drug from the reservoir at a reduced pressure relative to the impulse generating means,

means (412) for selectable setting a dose of drug to be expelled,

means (422) for actuating the impulse generating means and the drive means, and

actuatable first release means, whereby actuation of the first release means causes release of the impulse generator thereby expelling an amount of drug at a high pressure from the impulse chamber through the outlet nozzle (421), and

actuatable second release means (413), whereby actuation of the second release means causes release of the drive means for subsequent expelling of the set dose from the reservoir via the impulse chamber through the outlet nozzle.

18. A combination as in claim 15, wherein the impulse generator comprises a piston (240, 340) adapted for deforming the deformable chamber portion (250, 350), a rotatable cam (241, 341) for moving the piston, and a drive mechanism for driving the cam.

19. A combination as in claim 18, wherein the drive mechanism comprises a torsion spring (380), an actuator (360, 370) for bringing the torsion spring in an activated state, and a release (330) for releasing the activated spring and thereby rotate the cam.