Stent with pockets for containing a therapeutic agent
First Claim
Patent Images
1. A medical device for delivering a therapeutic agent comprising:
- (a) a stent having a sidewall comprising a plurality of struts, at least a first opening in the sidewall, and a first sidewall surface at least partially defined by the plurality of struts and the first opening;
(b) a first layer disposed over at least a part of the first sidewall surface, wherein at least a portion of the first layer extends over a part of the first opening;
(c) a second layer disposed over at least a part of the first sidewall surface, wherein at least a portion of the second layer is disposed over the portion of the first layer that extends over the first opening, (d) at least a first pocket disposed about at least a portion of the first opening;
wherein the pocket is defined at least in part by the first layer and at least in part by the second layer; and
(e) a therapeutic agent contained in the first pocket.
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Abstract
A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
89 Citations
40 Claims
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1. A medical device for delivering a therapeutic agent comprising:
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(a) a stent having a sidewall comprising a plurality of struts, at least a first opening in the sidewall, and a first sidewall surface at least partially defined by the plurality of struts and the first opening;
(b) a first layer disposed over at least a part of the first sidewall surface, wherein at least a portion of the first layer extends over a part of the first opening;
(c) a second layer disposed over at least a part of the first sidewall surface, wherein at least a portion of the second layer is disposed over the portion of the first layer that extends over the first opening, (d) at least a first pocket disposed about at least a portion of the first opening;
wherein the pocket is defined at least in part by the first layer and at least in part by the second layer; and
(e) a therapeutic agent contained in the first pocket. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A medical device for delivering a therapeutic agent comprising:
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(a) a stent having a sidewall comprising a plurality of struts, at least a first opening in the sidewall, an outer sidewall surface at least partially defined by the plurality of struts and the first opening, and an inner sidewall surface at least partially defined by the plurality of struts and the first opening;
(b) a first layer disposed over at least a portion of the outer sidewall surface, wherein at least a portion of the first layer extends over a part of the first opening, and wherein the first layer is bound to at least a portion of the stent;
(c) a second layer disposed over at least a portion of the inner sidewall surface, wherein at least a portion of the second layer extends over the first opening, (d) at least a first pocket disposed about at least a portion of the opening;
wherein the pocket is defined at least in part by the first layer and at least in part by the second layer; and
(e) a therapeutic agent contained in the first pocket.
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39. A medical device for delivering a therapeutic agent comprising:
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(a) a stent having a sidewall comprising a plurality of struts, at least a first opening in the sidewall, an outer sidewall surface defined by the plurality of struts and the opening, and an inner sidewall surface defined at least partially by the plurality of struts and the opening;
(b) a first layer disposed over at least a portion of the outer sidewall surface, wherein at least a portion of the first layer extends over a part of the first opening;
(c) a second layer disposed over at least a part of the inner sidewall surface, wherein at least a portion of the second layer extends over the opening, and wherein the second layer is bound to at least a portion of the first layer, (d) at least a first pocket disposed about at least a portion of the opening;
wherein the pocket is defined at least in part by the first layer and at least in part by the second layer; and
(e) a therapeutic agent contained in the first pocket.
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40. A medical device for delivering a therapeutic agent comprising:
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(a) a stent comprising a sidewall comprising at least a first strut and a second strut, and at least a first opening in the sidewall, wherein the first strut and the second strut each comprise an outer surface, an inner surface and at least one side surface;
(b) a first layer bound to a side surface the first strut and bound to a side surface of the second strut, wherein at least a portion of the first layer extends over a portion of the first opening;
(c) a second layer bound to a side surface of the first strut and bound to a side surface of the second strut, wherein at least a portion of the second layer extends over a portion of the first opening;
(d) at least a first pocket disposed about at least a portion of the opening;
wherein the pocket is defined at least in part by the first layer and at least in part by the second layer; and
(e) a therapeutic agent contained in the first pocket.
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Specification