Gateway platform for biological monitoring and delivery of therapeutic compounds

• US 20070060800A1
• Filed: 04/25/2006
• Published: 03/15/2007
• Est. Priority Date: 06/29/2001
• Status: Active Grant

• Current Assignee: PhiloMetron Inc.
• Original Assignee: PhiloMetron Inc.
• Inventors: Merz, Diethard, Drinan, Darrel, Edman, Carl
• Granted Patent: US 8,632,463 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 2560/0271 using a remote monitoring unit
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 40/67 for remote operation
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
• CPC Class Codes: Y10S 128/903 : Radio telemetry
• CPC Class Codes: Y10S 128/904 : Telephone telemetry

Abstract

The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party. The device provides for a universal platform for sensors, and further provides for the automatic compensation or distribution of devices or bioactive agents at appropriate levels and/or intervals in response to deviations or other states sensed in various physiological parameters.

Claims

1. A system for ambulatory physiological monitoring comprising:

at least one adhesive patch positioned on at least a portion of a subject, said patch comprising a plurality of sensors and at least one communication module, said sensors being configured to sense one or more physiological parameters comprising at least electrical impedance;

a data collection unit configured to receive information collected from said sensors from said communication unit.

2. The system of claim 1, additionally comprising a remote data management system configured to receive information from said data collection unit and process said information.

3. The system of claim 1, wherein said adhesive patch is secured to at least a portion of a thorax of said subject.

4. The system of claim 1, additionally comprising a temperature sensor.

5. The system of claim 1, additionally comprising a subsurface temperature sensor.

6. The system of claim 1, wherein said data collection unit is also configured to process information before sending information to said remote data management system.

7. The system of claim 1, comprising a timer for associating at least one measurement with an absolute time the measurement was taken.

8. The system of claim 1, wherein said remote database is configured to establish an individual baseline parameter value.

9. The system of claim 1, wherein the data management system provides feedback to the data collection unit and/or the communication module.

10. The system of claim 1, wherein said feedback comprises diagnostic knowledge.

11. The system of claim 1, wherein said feedback comprises actions and/or instructions.

12. The system of claim 1, comprising a plurality of communication modules.

13. The system of claim 1, comprising a plurality of data collection units.

14. A device comprising:

a portable hydration monitoring probe dimensioned to be continuously borne by an organism, the probe comprising

a supply of electrical power,

at least one electrode to exchange electrical energy from the supply with a local portion of the organism bearing the probe,

a controller to generate data representing a result of the hydration monitoring, the result reflecting a local bioelectric impedance based on the exchange of electrical energy at the electrode, and

a data communication device configured to wirelessly communicate the data representing the hydration monitoring result to a remote apparatus.

15. The device of claim 14, wherein said portable hydration monitoring probe is configured as a patch probe.

16. The device of claim 14, additionally comprising a temperature sensor.

17. The device of claim 14, comprising a plurality of electrodes.

18. The device of claim 17, wherein said electrodes are attached to an adhesive patch configured to be applied to the skin of a subject.